… These insights, among others, have not only improved our understanding of CRC
pathophysiology but have also opened the door to the discovery of new disease biomarkers and …

… DNA repair, chromosome instability, microsatellite instability, and … molecular subgroups of
colorectal tumors that develop via … pathogenesis and the different types of colorectal tumors, …

… The molecular pathogenesis of solid tumour was first assessed in colorectal … The
classical pathway of colorectal cancer (CRC) progression was hypothesized to involve an “adenoma–…

… , which has worse prognosis than sporadic colorectal cancer. Until recently, understanding
of pathogenesis in inflammatory bowel disease-associated colorectal cancer was restricted to …

… The acquisition of age-related hypermethylation of multiple genes in colon cancer is important
for studying colon cancer development. As mentioned earlier, methylation of genes such …

… Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder associated
with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may …

… Therefore, a deep understanding of epigenetic changes related to CRC pathogenesis might
help develop epigenetic-based biomarkers for CRC diagnosis and prognosis, and hence, …

… In this review, we summarize novel genomic and transcriptomic biomarkers as well as
signatures reported recently with prognostic and predictive potentials in stage II/III CRC. We …

… Compared with gene mutation that is irreversible, epigenetic inheritance is reversible …
epigenetic inheritance in the inflammation-cancer transformation may elucidate the pathogenesis …

… FOX gene deregulation in cancer pathophysiology brings consequences regarding its
onset, maintenance, progression and drug resistance. FOX molecules constitute therefore …