Toxicological Effects of Copaiba Oil (Copaifera spp.) and Its Active Components

CC Cardinelli, JEAE Silva, R Ribeiro, VF Veiga-Junior… - Plants, 2023 - mdpi.com
… of oil that have interesting characteristics and highly bioactive … mice for genotoxicity
assessment, commercial copaiba oil at doses … acid, a resinoid clerodane diterpene present in …

Antinociceptive activity of Copaifera officinalis Jacq. L oil and kaurenoic acid in mice

DP Dalenogare, PR Ferro, SDT De Prá, FK Rigo… - …, 2019 - Springer
oil has 13.8% of kaurenoic acid, a diterpene that can also be … genotoxicity and mutagenicity
in Copaifera officinalis oil and … , Copaiba officinalis oil and kaurenoic acid presented an …

Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test

JL Damasceno, YF Arnet, GC Fortunato… - Evidence‐Based …, 2019 - Wiley Online Library
Kaurenoic acid is a naturally occurring diterpene found in … and genotoxicity determinations
evidenced that Copaiba oil … of kaurenoic acid, a bioactive diterpenoid extracted from C. …

[PDF][PDF] Research Article Investigation of Safety Profile of Four Copaifera Species and of Kaurenoic Acid by Salmonella/Microsome Test

JL Damasceno, YF Arnet, GC Fortunato, L Girotto… - 2019 - academia.edu
Kaurenoic acid is a naturally occurring diterpene found in … and genotoxicity determinations
evidenced that Copaiba oil … of kaurenoic acid, a bioactive diterpenoid extracted from C. …

[PDF][PDF] Copaiba oil as a natural product challenge in the chemistry, pharmacological and biotecnological fields

ML de Medeiros, JR de Oliveira Netto… - APPLICATIONS AND … - researchgate.net
… and purification of the bioactive copaiba oil constituents. In this … Genotoxicity evaluation of
copaiba oil, their volatile … , as well as to the diterpene kaurenoic acid. The anti-inflammatory …

Chemistry, Biological Activities, and Uses of Copaiba Oil Resins

MCF de Lima, R Ribeiro, JE Almeida e Silva… - Gums, Resins and …, 2022 - Springer
… a natural source of this diterpene in oils of different species [… , full of bioactive diterpenes,
can become a source of copalic, … causes selective growth inhibition and genotoxicity in MCF-7 …

[HTML][HTML] Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus—A review

C Arruda, JAA Mejía, VP Ribeiro, CHG Borges… - Biomedicine & …, 2019 - Elsevier
… , such as: kaurenoic acid, kaurenol, copalic acid, agathic acid, … Copalic acid (184), a
labdane-type diterpene, stands out … , in 1560, where he mentioned copaiba oil uses. Since then, …

Antimicrobial and cytotoxic effects of the Copaifera reticulata oleoresin and its main diterpene acids

ALP Barbosa, A Wenzel-Storjohann, JD Barbosa… - Journal of …, 2019 - Elsevier
… bacteria for ent-copalic acid and ent-kaurenoic acid (4), with … aim of the present study was
to systematically evaluate the … and the pure diterpene components of copaiba are useful in …

Phytochemical analysis, in vitro antioxidant capacity and toxicity assessment of Copaifera paupera oleoresin

D Liviac, P Raunelli, R Alvis, S Puente, I Best… - Pharmacognosy …, 2019 - phcogj.com
… had evaluated the kaurenoic acid, a bioactive terpenoid present … upper were genotoxic in
V79 cells. Another parameter that … diterpenoid present in Copaiba oil. Food Chem Toxicol. 2006…

Effect of the kaurenoic acid on genotoxicity and cell cycle progression in cervical cancer cells lines

SMM da Rocha, PC dos Santos Cardoso… - Toxicology in Vitro, 2019 - Elsevier
… To date, few studies have evaluated the bioactivity of kaurenoic acid, although the … to
demonstrate that kaurenoic acid (30 and 60 μg/mL), a diterpene obtained from copaiba, promotes …