Innovative animal model of DSS-induced ulcerative colitis in pseudo germ-free mice

S Gancarcikova, S Lauko, G Hrckova, Z Andrejcakova… - Cells, 2020 - mdpi.com
… The antibiotic-treated or pseudo germ-free (PFG) miceexposed to the highest concentration
of DSS (AM5) we detected a significant positive correlation between DAI and the epithelial

[HTML][HTML] Nod2 influences microbial resilience and susceptibility to colitis following antibiotic exposure

A Goethel, W Turpin, S Rouquier, G Zanello… - Mucosal …, 2019 - Elsevier
… produced by neutrophils and epithelial cells and released … DSS-induced colitis in the
germ-free Nod2 −/− recipients. … reg in antibiotic-treated Nod2 −/− mice following DSS exposure …

Antibiotics damage the colonic mucus barrier in a microbiota-independent manner

J Sawaed, L Zelik, Y Levin, R Feeney, M Naama… - Science …, 2024 - science.org
… , and antibiotic treatment of germ-free mice, we determined that … mice that received an FMT
from the PBS- or antibiotic-treated … sodium (DSS)–induced colitis. We reasoned that this is the …

Beneficial effect of faecal microbiota transplantation on mild, moderate and severe dextran sodium sulphate-induced ulcerative colitis in a pseudo germ-free animal …

S Lauko, S Gancarcikova, G Hrckova, V Hajduckova… - Biomedicines, 2023 - mdpi.com
… 18 mice) control group without induction of ulcerative colitis and … with the mechanism of
epithelial damage, particularly if the … group DSS-FMT exposed to 5% DSS revealed considerable …

The germ-free mice monocolonization with Bacteroides fragilis improves azoxymethane/dextran sulfate sodium induced colitis-associated colorectal cancer

YP Lee, CC Chiu, TJ Lin, SW Hung… - …, 2019 - Taylor & Francis
… DNA damage and mutations of the colonic epithelial cells. … this mice strain is feasible
and susceptible used for AOM/DSS… mucosa epithelial cells was observed in the BF/AOM/DSS

[HTML][HTML] Antibiotics exacerbated colitis by affecting the microbiota, Treg cells and SCFAs in IL10-deficient mice

B Shen, J Hu, H Song, Z Wang, J Fan, Y Sun… - Biomedicine & …, 2019 - Elsevier
… , germ-free IL10 -/- mice do not develop spontaneous colitis [4… colitis induced by DSS but
also has no effect on established … in the antibiotic-treated and water-treated IL10 −/− mice, we …

Gut microbiota shape the inflammatory response in mice with an epithelial defect

R Wang, M Moniruzzaman, KY Wong, P Wiid… - Gut …, 2021 - Taylor & Francis
… By comparing mice in conventional and germ-free conditions, and by in vitro organoid …
Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis

Antibiotic treatment protocols and germ-free mouse models in vascular research

F Bayer, S Ascher, G Pontarollo… - Frontiers in …, 2019 - frontiersin.org
… of germ-free (axenic) and broad-spectrum antibiotic-treated … cecum, GF mice are less
susceptible for colonic inflammation, … to arterial injury, was increased in antibiotic treated rats. …

Gut microbiota-derived propionate regulates the expression of Reg3 mucosal lectins and ameliorates experimental colitis in mice

D Bajic, A Niemann, AK Hillmer… - … Crohn's and Colitis, 2020 - academic.oup.com
… the mouse caecum almost to a level of germ-free [GF] mice that … 16S rRNA analyses from
faeces of antibiotic-treated mice was … after injury, we administered AE to DSS-treated mice and …

Intestinal epithelial AMPK deficiency causes delayed colonic epithelial repair in DSS-induced colitis

S Olivier, H Diounou, C Pochard, L Frechin, E Durieu… - Cells, 2022 - mdpi.com
… To evaluate the impact of AMPK deletion on colonic mucosal injury and epithelial wound
repair after colitis, IEC AMPK KO and WT mice were exposed to 2.5% (w/v) DSS in drinking …