Landscape of T follicular helper cell dynamics in human germinal centers

E Donnadieu, KB Reisinger, S Scharf… - The Journal of …, 2020 - journals.aai.org
… the dynamics of these cells in germinal centers (GC) and their cross-talk with B cells upon an
… and soluble signals support survival and differentiation of GC B cells [for a review, see (1)]. …

T follicular cells: The regulators of germinal center homeostasis

F Ribeiro, E Perucha, L Graca - Immunology Letters, 2022 - Elsevier
… the formation of germinal centres (GCs), where specialized T follicular helperT follicular
helper cells … Tfh cells provide crucial signals to B cells, through the production of interleukin (IL)−…

Dynamic regulation of TFH selection during the germinal centre reaction

J Merkenschlager, S Finkin, V Ramos, J Kraft… - Nature, 2021 - nature.com
… Here we report on the dynamic behaviour of T follicular helper cell clones during the germinal
centre … To examine the role of TCR signalling to T FH cell proliferative responses, we used …

T follicular regulatory cells: Guardians of the germinal centre?

C Fahlquist Hagert, SE Degn - Scandinavian Journal of …, 2020 - Wiley Online Library
B cells a dependence on centrally tolerant T follicular helper … and contact cognate B cells,
eliciting further signals that fix the Tfh … The dynamic balance between the two subsets is thought …

Germinal center cells turning to the dark side: neoplasms of B cells, follicular helper T cells, and follicular dendritic cells

R Munguia-Fuentes, RA Maqueda-Alfaro… - Frontiers in …, 2021 - frontiersin.org
… 1970’s established the essential role of T helper cells in antibody responses. Hapten-protein …
Then, it was described that this help from T cells consisted in co-stimulatory signals through

[HTML][HTML] Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells

CH Yeh, J Finney, T Okada, T Kurosaki, G Kelsoe - Immunity, 2022 - cell.com
… are defined by a Bcl6 + CXCR5 hi PD-1 hi phenotype, but only a minor fraction of these
reside in germinal centers (GCs). Here, we examined whether GC-resident and -nonresident Tfh …

Expression of Foxp3 by T follicular helper cells in end-stage germinal centers

JT Jacobsen, W Hu, TB R. Castro, S Solem, A Galante… - Science, 2021 - science.org
… the GC reaction are T follicular helper (T FH ) cells characterized by … T FH cells provide
mitogenic signals essential for the … whether the dynamics of Foxp3 expression by GC T cells could …

T follicular regulatory cells: choreographers of productive germinal center responses

Y Lu, J Craft - Frontiers in Immunology, 2021 - frontiersin.org
… of T follicular helper cells, and are among a group of previously described Treg … to seed early
germinal centers (GCs) (7). … and cMyc signaling which are upregulated in GC B cells having …

T follicular helper cell heterogeneity: time, space, and function

W Song, J Craft - Immunological reviews, 2019 - Wiley Online Library
… (SLOs) where they provide help to B cells in germinal centers (GCs) to … to obtain signals from
other cell types, which in turn alters … of Tfh cells marked by the dynamic phenotypic changes …

Germinal center reaction

C Huang - B Cells in Immunity and Tolerance, 2020 - Springer
Germinal centers (GCs) are transient microstructures formed … cells including T follicular helper
(Tfh) cells and follicularcellular dynamics of the GC reaction, the mechanics of high-affinity …