Brain trauma, glucocorticoids and neuroinflammation: dangerous liaisons for the hippocampus

IG Komoltsev, NV Gulyaeva - Biomedicines, 2022 - mdpi.com
… in the level of excitatory amino acids in the extracellular space [49]. … MCAO induces
accumulation of the pro-inflammatory … induced by intra-amygdaloid injections of kainic acid. Eur. J. …

Insights into the therapeutic potential of glucocorticoid receptor modulators for neurodegenerative diseases

AF De Nicola, M Meyer, R Guennoun… - International journal of …, 2020 - mdpi.com
… of the behavioral, inflammatory, excitatory, and cell-death-… in the hippocampus in the kainic
acid model of excitotoxicity [53]. … 25–35 peptide accumulation disappeared after treatment …

Neuroinflammation and neuronal loss in the hippocampus are associated with immediate posttraumatic seizures and corticosterone elevation in rats

IG Komoltsev, SO Frankevich, NI Shirobokova… - International Journal of …, 2021 - mdpi.com
… K+, a decrease in Ca2+, changes in pH, accumulation of … excitatory neurotransmission [7].
Effects of GCs on neuronal excitability mediated by mineralocorticoid and glucocorticoid

Excitatory amino acid transporters in physiology and disorders of the central nervous system

AR Malik, TE Willnow - International journal of molecular sciences, 2019 - mdpi.com
… toxic accumulation of this amino acid in the extracellular space. In … of EAATs levels are
glucocorticoids which increase EAAT2 … of EAAT3 decreased after kainic acid stimulation [132,133] …

Levetiracetam ameliorated amyloidosis and tauopathy in mice with dexamethasone-induced Alzheimer's disease

X Zheng, HC Zhang, ZW Wei, YD Lv, FY Jin, J Zhu… - 2023 - researchsquare.com
… detrimental impact of chronic glucocorticoid exposure on AD … Extracellular accumulation of
Aβ in SPs in brains with AD is a … neurons via apoptosis inhibition in kainic acid (KA)-activated …

Glutamate-Mediated Excitotoxicity in the Pathogenesis and Treatment of Neurodevelopmental and Adult Mental Disorders

N Nicosia, M Giovenzana, P Misztak… - International Journal of …, 2024 - mdpi.com
… may result in the accumulation of excessive glutamate levels, … the extracellular space by
neuronal and astrocytic excitatory … the levels of the stress hormone glucocorticoid, which, in turn, …

Emerging evidence for the widespread role of glutamatergic dysfunction in neuropsychiatric diseases

T McGrath, R Baskerville, M Rogero, L Castell - Nutrients, 2022 - mdpi.com
… , potentially leading to a gradual accumulation of brain glutamine/… HPA glucocorticoids
provide feedback to the CNS and activate … This results in a widespread surge of excitatory

Pathophysiological Cascade of Events Leading to Epilepsy: Role of Inflammation

FO Kamel, HSAEK Eweis… - Journal of …, 2021 - research.manuscritpub.com
… depolarization caused by a giant synaptic excitatoryinduction [42,43]. In addition to
the hippocampus and cerebral cortex in kainic acid (KA) as well as electroconvulsive shockinduced

Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood–brain barrier during kainic acid-induced brain damage

H Yu, B He, X Han, T Yan - Open Life Sciences, 2021 - degruyter.com
Kainic acid (KA) is a glutamic acid analogue of excitatory toxicity, which can be used to simulate
excitatory toxicity caused … in young rats, accompanied by accumulation of microglia [28]. …

Intracellular signaling cascades in bipolar disorder

GH Jones, C Rong, AS Shariq, A Mishra… - Bipolar Disorder: From …, 2021 - Springer
… Glutamate is the most abundant excitatory neurotransmitter in the brain. It acts in three …
(MR) intracellular receptors. The human stress response increases glucocorticoid secretion, …