[HTML][HTML] Unraveling brain diseases: the promise of brain-on-a-chip models

L Cerutti, M Brofiga - Journal of Neuroscience Methods, 2024 - Elsevier
… Brain slice cultures are prepared by sectioning thin slices of … For this reason, glutamate
excitotoxicity and its consequences … Different receptor types interact with glutamate in ways that …

Analysis of Pentose Phosphate Pathway Inhibition on Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices

D Ponomareva, A Ivanov, P Bregestovski - 2023 - preprints.org
… it is still not clear if its impairment may contribute to the epileptogenesis and/or seizures …
glutamate release in rat prelimbic cortex through activation of dopamine D1 and sigma-1 receptor

Non-competitive AMPA glutamate receptors antagonism by perampanel as a strategy to counteract hippocampal hyper-excitability and cognitive deficits in cerebral …

L Bellingacci, M Tallarico, A Mancini, A Megaro… - …, 2023 - Elsevier
… In spite of the general believe that epileptic activity in AD … We confirmed increased epileptic-like
activity of slices … in the patient's brain, may lead to cognitive decline through disruption of …

Embelin ameliorates cognitive dysfunction and progression of kindling in pentylenetetrazol-induced kindling in mice by attenuating brain inflammation

U Hoda, S Jain, M Samim, GK Jain, NB Agarwal - Epilepsy & Behavior, 2021 - Elsevier
epileptiform discharges by activating the dopaminergic system … hyperactivity in
streptozotocin-infused rats, suggesting its … levels of glutamate and decreased levels of GABA and …

[HTML][HTML] Beneficial effects of capsaicin in disorders of the central nervous system

M Pasierski, B Szulczyk - Molecules, 2022 - mdpi.com
… axons which enhanced glutamate release in epileptic mice [53]. … epileptiform activity in
hippocampal slices in vitro, with … the effects of capsaicin in neocortical pyramidal neurons in vitro. …

Changes in Targets as an Explanation for Drug Resistance in Epilepsy

C Martínez-Aguirre, D Fonseca-Barriendos… - … in Epilepsy: From …, 2023 - Springer
… membranes from DR-MTLE patients and in neocortical slicesEpileptic activity in preclinical
models has been associated … glutamate receptors, neurotensin and dopamine receptors, …

Na+-K+-ATPase functions in the developing hippocampus: regional differences in CA1 and CA3 neuronal excitability and role in epileptiform network bursting

LR Shao, R Janicot… - Journal of …, 2021 - journals.physiology.org
… to sustain ongoing epileptiform activity and disrupt network … did not change epileptiform
activity (n = 4 slices, not shown). At … greatly impair the efficacy of glutamate reuptake and release, …

Cannabinoids, TRPV and nitric oxide: the three ring circus of neuronal excitability

G Gambino, V Rizzo, G Giglia, G Ferraro… - Brain Structure and …, 2020 - Springer
… eCB contributes to synaptic function by regulating processes … Taking into account bioelectric
activity, epileptic discharges … Overall, it was found an excessive glutamate transmission

[HTML][HTML] Combined Treatment of Levetiracetam and Mesenchymal Stem Cells Reverses Behavioral and Biochemical Aberrations in the Acute Phase of Experimental …

MI Hegazy, AM Asaad… - Biomedical and …, 2022 - biomedpharmajournal.org
… sectioning at 4 microns thick slices by rotary microtome. The … , glutamate and dopamine
levels of acute epileptic rat model. … area involved in the epileptic activity 80 and indicating active …

Diversity and function of corticopetal and corticofugal GABAergic projection neurons

S Melzer, H Monyer - Nature Reviews Neuroscience, 2020 - nature.com
… Indeed, many neocortical and archicortical GABAergic … to metabotropic glutamate receptor
1A (mGluR1A) expression, activity … was obtained in acute slice preparations in which septo–…