[HTML][HTML] Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate

D MacKeigan, M Feja, S Meller, L Deking… - Neurobiology of …, 2023 - Elsevier
… Finally, we performed slice-electrophysiology experiments to … -ST) test in our female rats, we
first performed a systemic VPA … reduced firing rates of glutamatergic STN neurons upon VPA …

Bioanalytical tools for unraveling part of the puzzle of the biochemical phenomena in epilepsy: neuromediators and antiepileptic drugs

BM da Fonseca - 2019 - search.proquest.com
… of aspartate, glutamate, glutamine, taurine and gamma-aminobutyric acid in rat brain. Local
… of neuronal epileptiform discharges due to increased neuronal activity. However, the specific …

Chemoarchitectural Signatures of Subcortical Shape Alterations in Generalized Epilepsy

W Liao, Y Meng, J Xiao, S Yang, J Li, Q Xu, Q Zhang… - 2024 - researchsquare.com
… element contributing to the development of epileptic seizures29… Muscarinic acetylcholine
receptor-mediated effects in slices … at human and rat M2 and M4 mAChRs in neocortex. Naunyn-…

Anatomical imaging of the piriform cortex in epilepsy

JC Young, DN Vaughan, HM Nasser… - Experimental neurology, 2019 - Elsevier
… lobe component into the insular neocortex. In imaging the … Induced seizures from area
tempestas recruit epileptic activity … hippocampus, with glutamate excitotoxicity hypothesized as …

Role of Ionotropic Glutamate Receptors in Neurodegenerative and Other Disorders

L Ragnarsson, PR Dodd, MR Latif - Handbook of Neurotoxicity, 2023 - Springer
… determine the contribution of kainate receptor block to … receptors and has showed antiParkinsonian
effect in both rat … in vivo and epileptiform activity in hippocampal slices induced by …

Controlling absence seizures from the cerebellar nuclei via activation of the Gq signaling pathway

JC Schwitalla, J Pakusch, B Mücher, A Brückner… - Cellular and Molecular …, 2022 - Springer
… only be the consequence of epileptic activity in the brain, but … [47] or the native metabotropic
glutamate receptor 1 (mGluR1) … in the neocortex. Furthermore, we found that specifically low …

Cholinergic modulation inhibits cortical spreading depression in mouse neocortex through activation of muscarinic receptors and decreased excitatory/inhibitory drive

S Zerimech, O Chever, P Scalmani, L Pizzamiglio… - …, 2020 - Elsevier
… actions, leading in neocortical slices to the generation of … the presence of the glutamate
receptor blocker kynurenic acid (… with our study (anesthetized rats vs acute mouse brain slices). …

Kainate receptors modulating glutamate release in the cerebellum

P Losada-Ruiz, R Falcón-Moya… - Biogenic Amines in …, 2019 - books.google.com
… KAR-mediated presynaptic facilitation of glutamate release in cerebellar slices, supporting
the … Does increased excitatory drive from the subthalamic nucleus contribute to dopaminergic

Cortical spreading depression: culprits and mechanisms

AA Mathew, R Panonnummal - Experimental brain research, 2022 - Springer
… using chick retina and neocortical slices. Induction of CSD in … releases glutamine and activates
glutamatergic transmission… the rat neocortex that dopamine can acts on the D2 receptors

Repurposed molecules for antiepileptogenesis: Missing an opportunity to prevent epilepsy?

P Klein, A Friedman, MQ Hameed, RM Kaminski… - …, 2020 - Wiley Online Library
epileptiform activity and stimulation-elicited hyperexcitability in neocortical slices from the …
posttraumatic downregulation of glutamate transport and enhances glutamate clearance in …