[HTML][HTML] N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease

C Morland, K Nordengen - International Journal of Molecular Sciences, 2022 - mdpi.com
… In humans, mGluR3 is strongly expressed in the neocortex, caudate … NAAG to cell cultures
or brain slices are due to the contamination of … of epileptic activity [57,58]. The modulation of …

Impact of open channel blockers on the surface dynamics and organization of NMDA receptors

A Fernandes - 2020 - theses.hal.science
… and Hélène Gréa, who directly contributed to this project. A … N-Methyl-D-Aspartate glutamate
receptors (NMDAR) are key … Finally, NMDAR reach the synapse through lateral diffusion. …

[HTML][HTML] Glial glutamate transporter-mediated plasticity: system xc-/xCT/SLC7A11 and EAAT1/2 in brain diseases

M Dahlmanns, JK Dahlmanns, N Savaskan… - Frontiers in Bioscience …, 2023 - imrpress.com
… release glutamate via system x c - , which evokes epileptic activity in … In human epileptic foci
in the neocortex, EAAT2 protein … In hippocampal rat brain slices, convulsive agents such as …

[HTML][HTML] GABAA Receptor-Stabilizing Protein Ubqln1 Affects Hyperexcitability and Epileptogenesis after Traumatic Brain Injury and in a Model of In Vitro Epilepsy in …

T Kürten, N Ihbe, T Ueberbach, U Distler… - International journal of …, 2022 - mdpi.com
… with an enhanced glutamatergic signaling, resulting in a … , we evoked epileptiform activity
in acute brain slices according to … lead to an enduring propensity towards epileptiform activity, …

TRPV1 channels in nitric oxide-mediated signalling: Insight on excitatory transmission in rat CA1 pyramidal neurons

G Gambino, D Gallo, A Covelo, G Ferraro… - Free Radical Biology …, 2022 - Elsevier
… alone suppressed excitatory transmission in the neocortex [25]. The … transmission of CA1
pyramidal neurons in rat brain slices. … excitatory glutamate release and its post-synaptic activity

… of ancient retrovirus, forms virus-like particles, which are abundantly generated by neurons during epileptic seizures, and affects epileptic susceptibility in rodent …

DA Sibarov, V Tsytsarev, A Volnova… - Frontiers in …, 2023 - frontiersin.org
… It is known that the epileptic activity of neurons depends on … Activation of calcium entry via
ionotropic glutamate receptors, … were studied, except 17 neocortical temporal lobe samples in …

[HTML][HTML] … of the Effects of Pentose Phosphate Pathway Inhibition on the Generation of Reactive Oxygen Species and Epileptiform Activity in Hippocampal Slices

D Ponomareva, A Ivanov, P Bregestovski - International Journal of …, 2024 - mdpi.com
… inhibition of the GABA A receptors [40] or an increase in spontaneous glutamate release [41]…
, it is expected that NADPH may contribute to the total autofluorescence signal. Changes in …

[HTML][HTML] Sigma-1 receptor and seizures

E Vavers, L Zvejniece, M Dambrova - Pharmacological Research, 2023 - Elsevier
… studies investigating glutamate and GABA receptor and voltage… Patch-clamp measurements
in brain slices of C57BL/6 J … R2 KO mice exhibit spontaneous epileptiform activity [53], while …

Glutamate/GABA Disbalance in Comparative Analysis of Radiation and Traumatic Brain Cortex Injury

VS Kokhan - Human Physiology, 2020 - Springer
… The glutamate/GABA system dominates in the neocortex and … It is not surprising that a
controlled lesion of the rat cortex causes a … epileptic activity [26], which highly correlates with the …

Pannexin-1 channels in epilepsy

MS Aquilino, P Whyte-Fagundes, G Zoidl… - Neuroscience Letters, 2019 - Elsevier
contributes to the dynamics observed during epileptic activity… P2X purinergic receptors to
release glutamate and provide … Of interest, adenosine production in hippocampal slices was …