[HTML][HTML] Revisiting the Allosteric Regulation of Sodium Cation on the Binding of Adenosine at the Human A2A Adenosine Receptor: Insights from Supervised …
… During the first step, the sodium ion approached the vestibular region of the A 2A AR and
interacted with negatively charged residues located at the second extracellular loop (ECL2). A …
interacted with negatively charged residues located at the second extracellular loop (ECL2). A …
Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives
… residues located at the intracellular part of the D 2 receptor … A 2A receptor dysfunction disrupts
glutamate homeostasis, 83 … The blockade of adenosine receptors by caffeine, for instance, …
glutamate homeostasis, 83 … The blockade of adenosine receptors by caffeine, for instance, …
Adenosine receptors in modulation of central nervous system disorders
H Choudhury, DK Chellappan… - Current …, 2019 - ingentaconnect.com
… , whereas stimulation of glutamate release results with activation of A2A ARs [69]. … The
four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: …
four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: …
[HTML][HTML] Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics …
K Prasad, EFJ de Vries, PH Elsinga… - International Journal of …, 2021 - mdpi.com
… of these receptors in modulating the excitatory glutamatergic … motifs (aspartic/phosphorylated
serine residues) in the C-terminal … of extracellular adenosine and adenosine receptors are …
serine residues) in the C-terminal … of extracellular adenosine and adenosine receptors are …
Structure and function of adenosine receptor heteromers
… (GPCR) superfamily, which is the most populated in the human … We have shown that these
domains contain Ser/Thr residues that … of adenosine, the regulation of glutamate release by …
domains contain Ser/Thr residues that … of adenosine, the regulation of glutamate release by …
Homo-oligomerization of the human adenosine A2A receptor is driven by the intrinsically disordered C-terminus
… Role of extracellular cysteine residues in the adenosine A2A … and intracellular signaling
in the A2A adenosine receptor. … sensing receptors with metabotropic glutamate receptors in …
in the A2A adenosine receptor. … sensing receptors with metabotropic glutamate receptors in …
Therapeutic potential of agonists and antagonists of A1, A2a, A2b and A3 adenosine receptors
… expression of adenosine receptors in the human body, the … residues, one is for agonist binding
and other for adenosine … well as glutamate and are localized in several neurons [53]. The …
and other for adenosine … well as glutamate and are localized in several neurons [53]. The …
Molecular and Structural Insight into Adenosine A2A Receptor in Neurodegenerative Disorders: A Significant Target for Efficient Treatment Approach
… by A 2A adenosine receptors in neurodegenerative disorders … The glutamate is released
when the presynaptic adenosine … with Glu and Gly residues located in the transmembrane (TM) …
when the presynaptic adenosine … with Glu and Gly residues located in the transmembrane (TM) …
[HTML][HTML] Molecular probes for the human adenosine receptors
… Increased understanding of these receptors is required to improve the success rate of
adenosine receptor drug discovery. To improve our understanding of receptor structure and …
adenosine receptor drug discovery. To improve our understanding of receptor structure and …
Binding Characterization of Agonists and Antagonists by MCCS: A Case Study from Adenosine A2A Receptor
… , and AA 3 R are subtypes of adenosine receptors. All these … -induced presynaptic reduction
in glutamate release. Therefore, … residue energy contribution to quantify certain residue’s …
in glutamate release. Therefore, … residue energy contribution to quantify certain residue’s …