… second extracellular loop 2 (EL2) to the recognition and binding of NECA (2). These included
the mutation of residues … a glutamic acid residue in the same position. It is speculated that …

… of human origin consists of 412 amino acid residues, however, A2AAR cloned from species
other than humans … The 2.6 angstrom crystal structure of a human A2A adenosine receptor …

… residues, histidine residue number 278 (His 278 ) in transmembrane domain 1 and glutamic
acid 13 in transmembrane domain 7 of the human … of the human A 2A adenosine receptor …

… D 4 receptor (D 4 R), the adenosine receptor subtypes A 1 R … (SP) of the human metabotropic
glutamate receptor type 5, the … residues located at the end of the helix (Fig. 5 C), near the …

… identified mammalian adenosine receptors (humans included… supplemented with 2 mM
L-glutamine, 1 mM sodium pyruvate… of adenosine derivatives with the S7.42 and H7.43 residues. …

… While this residue has been shown to be involved in ligand … , human embryonic kidney
(HEK) 293 cells were cultured as monolayers in DMEM supplemented with stable glutamine, 10% …

… (TIRF) imaging to investigate the conformational dynamics of the human A 2A adenosine
receptor (A 2A AR), a class AG protein-coupled receptor (GPCR), at the single-molecule level. …

… of adenosine receptors, to examine a multitude of receptor structures and novel ligands,
to gauge new pharmacology, and to evaluate clinical trials with adenosine receptor ligands. …

… refer to the region between residues 4.57 and 5.37 as the ECL2 loop. The composition of …
the ECL2 of the adenosine receptors A1 and A2a. The ECL2 of A1 and A2a share the same …

… in the hA 1 and hA 2A ARs, thanks to a glutamate residue on EL2 (E172 for hA 1 and E169
hA … hA 2B AR subtype; even if it bears a glutamate residue on EL2 as with the hA 1 and hA 2A …