… candidates at human A1, A2A, A2B… intracellular N- and C-termini; two trans-membrane
spanning regions (TM1 and TM2), a large extracellular loop, with 10 conserved cysteine residues …

… effects of neurotransmitters like glutamate [166-168]. Both A1 ARs and D1 dopamine …
Structures of human A1 and A2A adenosine receptors with xanthines reveal determinants of …

… being inserted between hydrophobic residues conserved among the human ARs (Phe171, …
of the interaction with the EL2 glutamate and TM6 asparagine residues (see above), with a …

… acid residues 201–215 of mouse adenosine A2A receptor [… to amino acid residues 147–166
of human A2BAR with … ) [49], mouse monoclonal anti-glutamate receptor 2 used to label the …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

… residues that are part of the second extracellular loop (ECL2) including the crucial phenylalanine
residue … of the N6-(D-ribos-1-yl)-adenosine derivative to the various human adenosine …

… In humans the ABC gene superfamily comprises about 50 members, which are organized in
… histidine residues that coordinate the zinc ion together with a conserved glutamate residue. …

… adenosine receptor (AR) ligands. In general, the modifications performed have led to compounds
having high to good human (h… with Thr277 7.42 for residues presenting a polar atom at …

… —an adenosine receptor blocker—to decreased risk of AD in … Glutamate then activates
postsynaptic glutamate receptors to … However, due to the physiological residual levels of A 2A R …

… Adenosine receptors are G protein-coupled receptors (GPCRs) involved in several processes
in the human … by accelerating the clearance of extracellular glutamate [125]. Moreover, it …