Inactivation of cysteine 674 in the sarcoplasmic/endoplasmic reticulum calcium ATPase 2 causes retinopathy in the mouse

G Liu, F Wu, H Wu, Y Wang, X Jiang, P Hu… - Experimental Eye …, 2021 - Elsevier
… adenovirus control. Together, these results confirmed that inactivation of C674 in endothelial
… , further confirming the contribution of C674 inactivation in endothelial cells to retinopathy. …

Redox-Resistant SERCA [Sarco (endo) plasmic reticulum calcium ATPase] attenuates oxidant-stimulated mitochondrial calcium and apoptosis in cardiac myocytes …

JB Goodman, F Qin, RJ Morgan, JM Chambers… - Circulation, 2020 - Am Heart Assoc
… SERCA, the major protein responsible for calcium uptake into the SR, is regulated by … of
SERCA in regulating SR calcium content and the susceptibility of SERCA to regulation by ROS, …

Cysteine glutathionylation acts as a redox switch in endothelial cells

A Lermant, CE Murdoch - Antioxidants, 2019 - mdpi.com
… levels, the antioxidant molecule glutathione (GSH) can bind to … with other posttranslational
regulatory mechanisms [11,12]. In … role in the regulation of endothelial cell homeostasis via …

Sarco/Endoplasmic Reticulum Ca2+ ATPase 2 Activator Ameliorates Endothelial Dysfunction; Insulin Resistance in Diabetic Mice

T Kimura, K Kagami, A Sato, A Osaki, K Ito, S Horii… - Cells, 2022 - mdpi.com
… OGTT is dependent on skeletal muscle function and blood flow regulated by endothelial
function. Hence, we examined how CDN1163 affected skeletal muscle and endothelial function. …

[HTML][HTML] S-glutathionylation, friend or foe in cardiovascular health and disease

NA Rashdan, B Shrestha, CB Pattillo - Redox Biology, 2020 - Elsevier
Glutathione is a low molecular weight thiol that is present at … Mutating Cys-674 prevents both
the NO induced S-… ) induces calcium oscillation in endothelial cells as well as an increase in …

[HTML][HTML] The substitution of SERCA2 redox cysteine 674 promotes pulmonary vascular remodeling by activating IRE1α/XBP1s pathway

W Yu, G Xu, H Chen, L Xiao, G Liu, P Hu, S Li… - … Pharmaceutica Sinica B, 2022 - Elsevier
sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is the critical redox regulatory
cysteine to regulateCa 2+ ATPase Cys-674 regulate endothelial cell calcium stores and …

Pathways for sensing and responding to hydrogen peroxide at the endoplasmic reticulum

JM Roscoe, CS Sevier - Cells, 2020 - mdpi.com
… acid to reversible forms (glutathione adducts, disulfides, … in HEK293 or human aortic endothelial
cells establish Cys674 as … TMX1, and whether Ca 2+ levels and/or H 2 O 2 regulate the …

Glutathione Dependent Regulation of VEGFR2

P Gopalakrishnan - 2019 - search.proquest.com
endothelial cell may regulate VEGFR2. In this study, we identified a lower GSH redox state as
one factor that regulates … of sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) …

Inactivation of cysteine 674 in the SERCA2 accelerates experimental aortic aneurysm

Y Que, X Shu, L Wang, P Hu, S Wang, R Xiong… - Journal of Molecular and …, 2020 - Elsevier
Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain …
Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as …

SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress

Y Wang, M Wang, H Su, J Song, M Ren, P Hu… - Free Radical Biology …, 2024 - Elsevier
… the key redox regulatory cysteine in regulating SERCA2 activity, … Sarcoplasmic/endoplasmic
reticulum calcium ATPase 2 (… in the sarcoplasmic reticulum (SR) and endoplasmic reticulum (…