Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease
V Granatiero, C Konrad, K Bredvik… - Life science …, 2019 - life-science-alliance.org
… regulation. Cells sense ER oxidative protein folding through H 2 O 2, which induces Nrf2
nuclear translocation. Nrf2 regulates the expression of GPx8, an ER glutathione … a regulatory …
nuclear translocation. Nrf2 regulates the expression of GPx8, an ER glutathione … a regulatory …
[HTML][HTML] Redox-resistant SERCA attenuates oxidant-stimulated mitochondrial calcium and apoptosis in cardiac myocytes and pressure overload-induced myocardial …
JB Goodman, F Qin, RJ Morgan, JM Chambers… - Circulation, 2020 - ncbi.nlm.nih.gov
… SERCA, the major protein responsible for calcium uptake into the SR, is regulated by … of
SERCA in regulating SR calcium content and the susceptibility of SERCA to regulation by ROS, …
SERCA in regulating SR calcium content and the susceptibility of SERCA to regulation by ROS, …
Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation
R Matsui, B Ferran, A Oh, D Croteau… - Antioxidants & Redox …, 2020 - liebertpub.com
… the enzymatic formation of glutathione adducts. The glyoxalase … Cys 674 of the
sarcoplasmic-endoplasmic reticulum calcium … ; sVEGFR1 (sFlt), soluble vascular endothelial …
sarcoplasmic-endoplasmic reticulum calcium … ; sVEGFR1 (sFlt), soluble vascular endothelial …
Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts
X Huang, X Lin, L Wang, Y Xie, Y Que, S Li, P Hu… - Biochemical …, 2022 - Elsevier
… Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain intracellular
calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating … endothelial …
calcium homeostasis, and its redox Cys 674 (C674) is the key to regulating … endothelial …
Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: Just What It Takes to Make a Blood Vessel
… use endothelial Ca 2+ signaling to regulate angiogenesis and vasculogenesis. The … induces
the formation of S-glutathione adducts on endothelial SERCA2b, which is indispensable to …
the formation of S-glutathione adducts on endothelial SERCA2b, which is indispensable to …
CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells
W Yu, Q Zhang, Y Qiu, H Chen, X Huang… - Clinical and …, 2023 - Taylor & Francis
… Cys 674 (C674) in the sarcoplasmic/endoplasmic reticulum … vWF staining showed the
endothelial cells (ECs) of arterioles, … In some experiments, we used ratio to control to avoid larger …
endothelial cells (ECs) of arterioles, … In some experiments, we used ratio to control to avoid larger …
Cross-talk between mechanosensitive ion channels and calcium regulatory proteins in cardiovascular health and disease
Y Wang, J Shi, X Tong - International Journal of Molecular Sciences, 2021 - mdpi.com
… NCX1 in smooth muscle and endothelium could play opposite roles in regulating blood … to
NCX1 through physical interaction in the Ca 2+ regulation [119]. Glutathione s-transferase pull-…
NCX1 through physical interaction in the Ca 2+ regulation [119]. Glutathione s-transferase pull-…
Hypoxia damages endothelial cell angiogenic function by reducing the Ca2+ restoring ability of the endoplasmic reticulum
K Yan, B Song, Y Zhen - Biochemical and Biophysical Research …, 2022 - Elsevier
… the Ca 2+ restoration ability of the ER by decreasing sarcoplasmic/endoplasmic reticulum Ca
2+ ATPase … There is no specific treatment in the control group. After the treatment, add MTT …
2+ ATPase … There is no specific treatment in the control group. After the treatment, add MTT …
Redox control of angiogenesis
K Schröder - Antioxidants & redox signaling, 2019 - liebertpub.com
… Those directly bind FGF and regulate endothelial spreading … Glutathione adducts induced
by ischemia and deletion of … SERCA ¼ sarcoplasmic–endoplasmic reticulum calcium ATPase …
by ischemia and deletion of … SERCA ¼ sarcoplasmic–endoplasmic reticulum calcium ATPase …
Multifunctional single-layered graphene quantum dots used for diagnosis of mitochondrial malfunction-related diseases
XL Jiang, JH Liu, YT Que, YM Que, PP Hu… - ACS Biomaterials …, 2019 - ACS Publications
… -based detection, and β-actin was involved as the internal control. … Cys-674 thiol of SERCA)
was then employed as the mouse model for the first time. Compared to WT, excessive Ca 2+ …
was then employed as the mouse model for the first time. Compared to WT, excessive Ca 2+ …