Nrf2 signaling links ER oxidative protein folding and calcium homeostasis in health and disease

V Granatiero, C Konrad, K Bredvik… - Life science …, 2019 - life-science-alliance.org
regulation. Cells sense ER oxidative protein folding through H 2 O 2, which induces Nrf2
nuclear translocation. Nrf2 regulates the expression of GPx8, an ER glutathione … a regulatory

[HTML][HTML] Redox-resistant SERCA attenuates oxidant-stimulated mitochondrial calcium and apoptosis in cardiac myocytes and pressure overload-induced myocardial …

JB Goodman, F Qin, RJ Morgan, JM Chambers… - Circulation, 2020 - ncbi.nlm.nih.gov
… SERCA, the major protein responsible for calcium uptake into the SR, is regulated by … of
SERCA in regulating SR calcium content and the susceptibility of SERCA to regulation by ROS, …

Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation

R Matsui, B Ferran, A Oh, D Croteau… - Antioxidants & Redox …, 2020 - liebertpub.com
… the enzymatic formation of glutathione adducts. The glyoxalase … Cys 674 of the
sarcoplasmic-endoplasmic reticulum calcium … ; sVEGFR1 (sFlt), soluble vascular endothelial

Substitution of SERCA2 Cys674 aggravates cardiac fibrosis by promoting the transformation of cardiac fibroblasts to cardiac myofibroblasts

X Huang, X Lin, L Wang, Y Xie, Y Que, S Li, P Hu… - Biochemical …, 2022 - Elsevier
Sarcoplasmic/endoplasmic reticulum Ca 2+ ATPase 2 (SERCA2) is vital to maintain intracellular
calcium homeostasis, and its redox Cys 674 (C674) is the key to regulatingendothelial

Endothelial Ca2+ Signaling, Angiogenesis and Vasculogenesis: Just What It Takes to Make a Blood Vessel

F Moccia, S Negri, M Shekha, P Faris… - International journal of …, 2019 - mdpi.com
… use endothelial Ca 2+ signaling to regulate angiogenesis and vasculogenesis. The … induces
the formation of S-glutathione adducts on endothelial SERCA2b, which is indispensable to …

CDN1163 alleviates SERCA2 dysfunction-induced pulmonary vascular remodeling by inhibiting the phenotypic transition of pulmonary artery smooth muscle cells

W Yu, Q Zhang, Y Qiu, H Chen, X Huang… - Clinical and …, 2023 - Taylor & Francis
Cys 674 (C674) in the sarcoplasmic/endoplasmic reticulum … vWF staining showed the
endothelial cells (ECs) of arterioles, … In some experiments, we used ratio to control to avoid larger …

Cross-talk between mechanosensitive ion channels and calcium regulatory proteins in cardiovascular health and disease

Y Wang, J Shi, X Tong - International Journal of Molecular Sciences, 2021 - mdpi.com
… NCX1 in smooth muscle and endothelium could play opposite roles in regulating blood … to
NCX1 through physical interaction in the Ca 2+ regulation [119]. Glutathione s-transferase pull-…

Hypoxia damages endothelial cell angiogenic function by reducing the Ca2+ restoring ability of the endoplasmic reticulum

K Yan, B Song, Y Zhen - Biochemical and Biophysical Research …, 2022 - Elsevier
… the Ca 2+ restoration ability of the ER by decreasing sarcoplasmic/endoplasmic reticulum Ca
2+ ATPase … There is no specific treatment in the control group. After the treatment, add MTT …

Redox control of angiogenesis

K Schröder - Antioxidants & redox signaling, 2019 - liebertpub.com
… Those directly bind FGF and regulate endothelial spreading … Glutathione adducts induced
by ischemia and deletion of … SERCA ¼ sarcoplasmicendoplasmic reticulum calcium ATPase

Multifunctional single-layered graphene quantum dots used for diagnosis of mitochondrial malfunction-related diseases

XL Jiang, JH Liu, YT Que, YM Que, PP Hu… - ACS Biomaterials …, 2019 - ACS Publications
… -based detection, and β-actin was involved as the internal control. … Cys-674 thiol of SERCA)
was then employed as the mouse model for the first time. Compared to WT, excessive Ca 2+ …