Guidelines for in vivo mouse models of myocardial infarction

ML Lindsey, KR Brunt, JA Kirk… - American Journal …, 2021 - journals.physiology.org
… a major coronary vessel, causing myocardial ischemia, clinically termed acute coronary …
the superiority of one MI animal model. Instead, we will provide recommendations on how the …

A review of myocardial ischaemia/reperfusion injury: pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment

M Gunata, H Parlakpinar - Cell biochemistry and function, 2021 - Wiley Online Library
… has been shown to reduce the infarct area and improve cardiac function in the experimental
… Our review will guide scientists and researchers in this field and it will contribute to the …

Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion

C De Villiers, PR Riley - Disease Models & Mechanisms, 2020 - journals.biologists.com
Animal models of MI are crucial tools to further our … min, but this time point is not well justified
against clinical criteria. … reduces infarct size in a mouse model of myocardial ischaemia-…

Myocardial ischemia-reperfusion injury and the influence of inflammation

M Algoet, S Janssens, U Himmelreich, W Gsell… - Trends in cardiovascular …, 2023 - Elsevier
… Acute myocardial infarction is caused by a sudden coronary … Statins, which are evidence
based guideline recommended … was evidenced by experimental animal models in which the …

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week

SM Davidson, P Ferdinandy, I Andreadou… - Journal of the American …, 2019 - jacc.org
… in experimental animal models of acute ischemia and reperfusion injury. However, translation
of these cardioprotective therapies into the clinical setting of acute myocardial infarction (…

Myocardial ischaemia–reperfusion injury and cardioprotection in perspective

G Heusch - Nature Reviews Cardiology, 2020 - nature.com
ischaemic myocardium from myocardial infarction is timely reperfusion. Successful salvage
of ischaemic myocardium from infarction by … that have been investigated in experimental and …

The pathophysiology of myocardial ischemia and perioperative myocardial infarction

M Smit, AR Coetzee, A Lochner - Journal of Cardiothoracic and Vascular …, 2020 - Elsevier
… abnormalities, or other criteria that meet the aforementioned … Ischemic myocardial injury
and infarction precipitated by an … myocardial ischemic event is high (typical presentation of …

Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols

C Penna, I Andreadou, M Aragno… - British journal of …, 2020 - Wiley Online Library
… We overview the available animal models of diabetes, investigating acute myocardial IRI …
elicited by limb RIC in a rat acute myocardial infarction model. This effect was associated with …

Human tissue-engineered model of myocardial ischemia–reperfusion injury

T Chen, G Vunjak-Novakovic - Tissue Engineering Part A, 2019 - liebertpub.com
… reliance on small animal models in preclinical studies. While … the actual ischemic insult—has
reduced the final infarct size … Committee on Cell Death guidelines.We determined changes …

The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection

DJ Hausenloy, W Chilian, F Crea… - Cardiovascular …, 2019 - academic.oup.com
… of sustained myocardial ischaemia is always associated with infarction. … experimental models,
98 and at autopsy of patients with non-reperfused AMI. In an ex vivo reperfusion rat model, …