Truncated Hemoglobin O Carries an Autokinase Activity and Facilitates Adaptation of Mycobacterium tuberculosis Under Hypoxia

MD Hade, D Sethi, H Datta, S Singh… - Antioxidants & redox …, 2020 - liebertpub.com
… bovis bacillus Calmette-Guerin (BCG) carries a potent nitric oxide (NO) scavenging activity
(… Mycobacterium leprae. The complexity in understanding the cellular function(s) of truncated

M. leprae HSP18 suppresses copper (II) mediated ROS generation: effect of redox stress on its structure and function

SK Nandi, A Chakraborty, AK Panda… - International journal of …, 2020 - Elsevier
… Ascenzi et al. demonstrated that M. leprae truncated hemoglobin is involved in scavenging
hydrogen peroxide and thereby helps the pathogen to survive and proliferate in host cells [27]…

[HTML][HTML] New Insights Into the Function of Flavohemoglobin in Mycobacterium tuberculosis: Role as a NADPH-Dependent Disulfide Reductase and D-Lactate …

N Thakur, AN Sharma, MD Hade, A Chhaya… - Frontiers in Cellular …, 2022 - frontiersin.org
… to ferric ions by lipid peroxide with the subsequent binding of … peroxide in the cell was
monitored by measuring the absorbance at 560 nm using the standard curve prepared from H 2 O

[HTML][HTML] Heme oxygenase-1 as a pharmacological target for host-directed therapy to limit tuberculosis associated immunopathology

KC Chinta, HT Pacl, A Agarwal, AJC Steyn - Antioxidants, 2021 - mdpi.com
… and patients infected with Mycobacterium tuberculosis (Mtb), … (Hx), a molecular scavenger
of heme, is known to rescue … as superoxide, hydrogen peroxide, hypochlorite, nitric oxide (NO), …

[HTML][HTML] Flavohaemoglobin: The pre-eminent nitric oxide–detoxifying machine of microorganisms

RK Poole - F1000Research, 2020 - ncbi.nlm.nih.gov
NO to NO 3 − via an NO dioxygenase activity. These include the truncated globin of
Mycobacterium tuberculosis… Evidence for a novel inducible anaerobic nitric oxide-scavenging

Investigating a novel protein-based cofactor: toward elucidating the catalase mechanism of Mycobacterium tuberculosis KatG

T Aziz - 2022 - etd.auburn.edu
… preparations of KatG upon reaction with H2O2 under sustained turnover conditions ……………
on enzyme absorption features during consumption of H2O2 under multiple-turnover/steady…

Proteomics of physiologically relevant stresses on model mycobacterium tuberculosis organisms, and the effects on virulence

M Ganief - 2023 - open.uct.ac.za
… to nitric oxide or hydrogen peroxide increases the survival of … In immortalised cells
overexpressing of scavenger receptor B1 (SR-… -bound truncated haemoglobin N (Rv1542c) …

Proteome Profiling of Mycobacterium tuberculosis Cells Exposed to Nitrosative Stress

AG Birhanu, M Gómez-Muñoz, S Kalayou, T Riaz… - ACS …, 2022 - ACS Publications
… the devastating effect of RNS by direct scavenging, iron sequestration, suppression of RNS
… by truncated hemoglobin (trHbN) and prevents inhibition of aerobic respiration by NO. Other …

Defenses of multidrug resistant pathogens against reactive nitrogen species produced in infected hosts

SM Carvalho, JZ Beas, MAM Videira… - Advances in Microbial …, 2022 - Elsevier
… , NO is produced endogenously by NO synthases (NOS), which convert L-arginine and oxygen
into L-citrulline and NO in a … In the first step, that requires one molecule of oxygen and two …

[HTML][HTML] Reactive species and pathogen antioxidant networks during phagocytosis

L Piacenza, M Trujillo, R Radi - Journal of Experimental Medicine, 2019 - rupress.org
… and concentrating on Mycobacterium tuberculosis and Trypanosoma … Hydrogen peroxide
and hydroxyl radicals … -derived • NO relies on the presence of the truncated hemoglobin N (…