… advances in defining pancreatic cancer subtypes and subtype… challenges in the clinical
development of pancreatic cancer … signaling pathways and transcription factors involved in cell …

… Fibroblasts in proximity to cancer cells are induced by transforming growth factor-β (TGFβ) …
of lung cancer and in KPC-based pancreatic cancer 61,62 , motivating the clinical translation …

… focus on the major transcription factors involved in angiogenesis during pancreatic cancer
(Fig. 2). … stellate cells; HGF hepatocyte growth factor; Ang-1 angiopoeitin-1; VEGF-A vascular …

… hepatocyte growth factor (HGF)/c-MET pathway. HGF is produced by PSCs and its receptor
c-MET is expressed on pancreatic cancer … dissemination of pancreatic cancer. Therapeutic …

… Pancreatic cancer is one of the most challenging cancers among gastrointestinal malignancies
due to various factors … inhibitor targeting epidermal growth factor receptor is currently the …

… treatment strategies particularly challenging. The … pancreatic cancer that has failed the
first line gemcitabine-based therapy, lapatinib, an inhibitor of both the epidermal growth factor …

… Another important pathway for tumour-stromal interactions is the hepatocyte growth factor/tyrosine-protein
kinase Met (HGF/c-MET) pathway. HGF is secreted by activated PSCs that in …

… The challenge now is to translate the pre-clinical … growth factor pathway of interest in PC,
is the HGF-c-MET pathway. PSCs secrete the precursor form of hepatocyte growth factor (HGF), …

… Following growth factor binding, receptor tyrosine kinases become phosphorylated and
then bind to signaling adapter proteins such as growth factor receptor-bound protein 2 (GRB2), …

… (14) Interestingly, proinflammatory gene-expression signatures clustered with dysregulation
of transforming growth factor beta (… The microbiome and hepatobiliary-pancreatic cancers. …