… In this study, platelet-derived growth factor α (PDGFRα)-positive cells made up approximately
half of stromal cells, with a third being double-positive for αSMA and PDGFRα. Whether the …

… regulated under the Pancreas transcription factor 1 (Ptf1)-… orthotopically implanted pancreatic
tumor growth derived from … A clinical challenge is the degree of immunosuppression that …

… to all other common cancer types. Targeted therapies for advanced pancreatic cancer based
on … , with only 3–5% showing even a short clinical benefit. There is, however, a molecular …

… form of liver cancer and the second most lethal type of cancer after pancreatic cancer [1]. …
The stemness of HCC cells is also supported by hepatocyte growth factor (HGF) secreted by …

… Indeed, there remain many challenging … pancreatic cancer cells, LDHA could also be
comprehensively regulated by deacetylation modification and other oncogenic transcription factors, …

… cause of cancer mortality worldwide in 2018. In the past few years, increasing attention
has been drawn on the hepatocyte growth factor/c-mesenchymal–epithelial transition factor (HGF/…

… growth factor (TGF), platelet-derived growth factor (PDGF), hepatocyte growth factor (HGF),
fibroblast growth factor (… growth factor (VEGF), and insulin-like growth factor (IGF), stimulate …

… and permanently activates KRAS protein, and then the protein serves on a molecular
switch to activate various signaling pathways and transcription factors in cells, inducing cell …

Pancreatic cancer is one of the leading causes of cancer death worldwide. Its high mortality
rate has remained unchanged for years. Radiotherapy and surgery are considered standard …

… We also discuss clinical challenges and the arising therapeutic opportunities in PDAC …
Neutrophils also produce hepatocyte growth factor (HGF) and proteolytic matrix …