… mutations result in nonviable phenotypes with dysplastic formation of the lungs, pituitary and
thyroid … article reviewed the heterogeneity of lung disease in NKX2–1 mutations, with a short …

… Phenotypic heterogeneity in tumor cell populations that … the phenotypic heterogeneity in
subtypes of thyroid cancers. … and inhibited the lung metastasis development in a thyroid cancer …

… NKX2-1 mutations are associated to the “brain-lung-thyroid” syndrome, a triad characterized
… the phenotypic heterogeneity (either inter or intra-familial) of subjects harboring mutation of …

… Our study identifies genetic determinants of TBX4 disease heterogeneity, inclusive of …
associated with later-onset lung disease. It draws important conclusions on genotype–phenotype …

… Moreover, based on data in cases with spatial and/or temporal heterogeneity, this study
proposes an evolutionary model from clones of lower aggressivity through the accumulation of “…

… Thyroid dyshormonogenesis is a heterogeneous group of hereditary diseases … and lung,
which is why some mutations in these genes cause syndromic phenotypes that are associated …

… Although PAH is heterogeneous, genetic defects relevant to pulmonary … Mutations in
the bone morphogenetic protein (BMP) receptor type 2 gene (BMPR2) and other BMP-associated …

… Genes associated with aggressive phenotype, such as TERT, are generally … Data on
the molecular heterogeneity of poorly differentiated carcinomas associated with well-differentiated …

… The phenotype associated with pathogenic variants in NKX2-… illustrates that mutations in
NKX2-1 are associated with a … Considering the heterogeneous and disabling nature of the …

… phenotype and prognosis of all Pulmonary Arterial Hypertension patients with disease-associated …
This study aimed to describe the phenotype of PAH associated with TBX4 variants. …