… Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its …
Additionally, in mouse models, the lack of ST3GAL4 is associated with platelet deficiency. CMP-N-…

… of new ligands with comparable or higher affinity and less … balance has great impacts on
ligand binding to the receptor. It … To confirm the lack of toxicity on a hepatocyte cell line closer to …

… of the payload to hepatocytes through a high-affinity interaction with the asialoglycoprotein
receptor (ASGPR). ASGPR directs the receptor-mediated uptake of the oligonucleotide via …

… on the cell surface upon ligand binding. Because it was … The two subunits of the human
asialoglycoprotein receptor … and receptor-expressing U87 cells by free uptake, in the absence of …

… affinity to the asialoglycoprotein receptor (ASGPR) in the nanomolar range of concentrations
and a high … The absence of such selectivity in the case of monovalent conjugates indicates …

… remained elusive due to the lack of high-resolution structures. … Like the asialoglycoprotein
receptor, additional calcium … mannose binding protein and likely results in a higher affinity of …

… demonstrate high affinity to the asialoglycoprotein receptor (… to several receptor subunits, the
monovalent parts of these ligands … PC3 cells or in the absence of the ligand (compound 14). …

… exit to the plasma membrane, in the absence or presence of S1R agonists or of ER stress. …
made with a protein known to have a type II orientation, asialoglycoprotein receptor H2a ( …

… are DNA analogs that bind with high affinity to DNA and RNA … -293 cells that lack this
receptor. The sequential conjugate … is the ligand for the asialoglycoprotein receptor (ASGPR), to …

… labeling peanut agglutinin (PNA), asialoglycoprotein receptor (ASGPR), and human carbonic
… of PNA using probes 2 and 4 in the presence or absence of a competitor. (d) SDS-PAGE …