… eCD4-Ig neutralizes every human immunodeficiency virus type 1 (… CD4-Ig or the CD4-binding
site antibody NIH45-46. We observed that a viral swarm selected with high concentrations …

… infection, neutralization, and cold-inactivation assays, we have … At higher levels of CD4,
incorporated CD4 abrogates viral … The recombinant viruses were then incubated in quadruplicate …

… we titrated the concentration of sCD4 or CD4mc necessary to … gp120-CD4 interaction that
neutralize HIV infection have been … Recombinant CD4-IgG2 in human immunodeficiency virus …

… to have significantly higher levels of neutralizing antibodies … systems for recombinant proteins,
we have investigated the feasibility … The induction of improved CD4 + T cell help may have …

… soluble CD4. The ability of a mAb to deliver a CIC does not correlate with its ability to neutralize
… Because we tested the mAbs for cytotoxicity at a relatively high concentration, we chose …

… human immunodeficiency virus (HIV) in vivo. Detailed investigations of resting human CD4 +
T cells have … that cultivation of resting CD4 + T cells in the presence of low concentrations of …

… not neutralized even at the maximum tested concentration (… investigated in the presence of
soluble CD4 (sCD4) in a … a recombinant gp120 protein alone vaccine exhibited a high level of …

… the control BG505-derived human immunodeficiency virus-1 (HIV… The recombinant viruses
were collected from the transfected … antibody directly isolated from a patient targeting the CD4 …

… neutralization by soluble CD4-based inhibitors. Schematic comparison of responses of
soluble CD4-based inhibitors and CD4-… exposed to neutralizing CD4-VLP concentrations, we …

… CD4 domain I with high affinity for gp120, good stability and solubility, exhibits broad and
potent neutralizing … at the concentration of 5 nmol/liter, as shown by the increased expression of …