Effect of MicroRNA145 on the multidrug resistance gene of ulcerative colitis in rats

P Wang, Y Chen, LM Zhang, SQ Yuan, SA Lu… - Life Sciences, 2021 - Elsevier
Multidrug resistance gene (MDR1a) and P-glycoprotein (P-gp… colitis (UC) is a type of
inflammatory bowel disease (IBD). It … In Ueda' study, P-gp is a 170-kDa membrane protein …

Modulation of expression/function of intestinal P-glycoprotein under disease states

T Murakami, E Bodor, N Bodor - Expert Opinion on Drug …, 2020 - Taylor & Francis
… ), involves P-glycoprotein (P-gp, or multidrug resistance gene … in obese rats, the AUC was
170% of the control, possibly due … -gp expression was strongly decreased in inflamed intestinal

Inflammatory pathway interactions and cancer multidrug resistance regulation

SA Mirzaei, F Dinmohammadi, A Alizadeh, F Elahian - Life sciences, 2019 - Elsevier
… P-gp is a 170-kDa membrane anchor protein and most … MDR1 expression in the inflamed
intestinal epithelium was … of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in …

Microbial metabolites orchestrate a distinct multi-tiered regulatory network in the intestinal epithelium that directs P-glycoprotein expression

SE Foley, MJ Dente, X Lei, BF Sallis, EB Loew… - Mbio, 2022 - Am Soc Microbiol
… a 170 kDa transmembrane protein encoded by the multidrug … (SNPs) in mdr1 and risk of
inflammatory bowel disease (IBD) (7… Though multidrug resistance protein 2 (MRP2, abcc2) and …

The impact of inflammation on the expression of drug transporters and metabolic enzymes in colonic tissue from ulcerative colitis patients

T de Waal, N Handin, J Brouwers, M Ferrante… - International Journal of …, 2022 - Elsevier
… The intestinal tract forms an important … colitis (UC), a chronic inflammatory bowel disease,
this barrier function is impaired leading to an abnormal immune response and inflammation of …

[HTML][HTML] Mechanism of multidrug resistance to chemotherapy mediated by Pglycoprotein

Y Tian, Y Lei, Y Wang, J Lai… - … Journal of Oncology, 2023 - spandidos-publications.com
… Chinese hamster ovary cells as a membrane glycoprotein with a molecular weight of ~170
of DOX and vincristine on MDR cells with high P-gp expression, which is dependent on the …

ABC transporters: regulation and association with multidrug resistance in hepatocellular carcinoma and colorectal carcinoma

MP Ceballos, JP Rigalli, LI Ceré… - Current medicinal …, 2019 - ingentaconnect.com
… as P-glycoprotein (P-gp/MDR1/ABCB1), multidrug resistance-… situations such as inflammatory
bowel disease and CRC [172]. … the expression and function of Pglycoprotein in intestinal

Multidrug resistance Gene-1 polymorphisms (C3435T and G2677T) and the risk of inflammatory bowel disease in Egyptian patients

R Marzaban, RM Samy, MA Kassem, M Atef - Arab Journal of …, 2024 - Elsevier
… candidate gene encoding a 170 kDa transmembrane protein pump termed P-glycoprotein
(Pgp)… Although its physiological function in the gut is unknown, its high expression levels imply …

Multidrug resistance P-glycoprotein (P-gp), glucocorticoids, and the stress response

E Bloise, SG Matthews - Stress: Physiology, Biochemistry, and Pathology, 2019 - Elsevier
… cancers, with particularly high levels in cells with high resistance to … P-gp is a 170 kDa
glycoprotein, primarily localized on the … P-gp is expressed in the placenta with the highest levels at …

[HTML][HTML] C3435T polymorphism of the ABCB1 gene in polish patients with inflammatory bowel disease: a case–control and meta-analysis study

P Petryszyn, R Dudkowiak, A Gruca… - Genes, 2021 - mdpi.com
… and large bowel epithelium, and its different expression may … (‘multidrug resistance protein
1/exp OR ‘multidrug resistance … OR ‘p glycoprotein’:ab,ti) AND (‘inflammatory bowel disease’/…