… processes, regulating obesity, insulin resistance, inflammation and energy metabolism [48].
It … the involvement of SIRTs on clinical trials for the treatment of metabolic disease is limited. …

… In a rodent model of insulin resistance, SRT1720 treatment … The study employed healthy
men and women with two … In spite of numerous reports on the endogenous substrates of sirtuins …

… the time of enhancement of insulin sensitivity.The maximum … implicated in lipid metabolism,
substrate transfer along with … larger double blind randomized, placebo controlled trials are …

… a high dose of quercetin aglycone (1095 mg) to 17 overweight, … blind, placebo-controlled,
randomized clinical trial, researchers … The effect of resveratrol in 11 obese men aged 52.5 ± 2.1 …

… Moreover, in a randomized, double-blind, placebo-controlled clinical trial, high-dose RSV
had no significant influence on BG and insulin sensitivity in obese human subjects (Poulsen et …

… HDACs in metabolic disorders, such as insulin resistance, and … the mitochondrial use of lipid
substrates as a source of energy. … However, in most of these clinical trials resveratrol had no …

… In a placebo-controlled trial, both grape extract and grape … with a moderate to high dose of
resveratrol (1 g/day) may help … positive effects concerning insulin resistance in obesity. This …

… fat is closely associated with numerous metabolic … body weight in obese adults when
supplemented with Res [40]. The mixed results of clinical trials using Res suggest that future studies …

… for 4 weeks, RSV significantly decreased insulin resistance [91]. … improved the metabolic
profile in a healthy obese man: RSV … , a clinical trial on 19 type 2 diabetic patients supplemented …

… of fat in the liver is associated with insulin resistance (… -blind placebo-controlled trials and
randomized clinical trials … forming units CFU per day, 23 high dose probiotic HD 1 per 10 at 10 …