HDAC inhibition induces autophagy and mitochondrial biogenesis to maintain mitochondrial homeostasis during cardiac ischemia/reperfusion injury
J Yang, J He, M Ismail, S Tweeten, F Zeng… - … and cellular cardiology, 2019 - Elsevier
… benefits of histone deacetylase (HDAC) inhibitors in murine and … have been shown to suppress
cardiac hypertrophy and I/R … And HDAC inhibitors blunt cardiac hypertrophy also through …
cardiac hypertrophy and I/R … And HDAC inhibitors blunt cardiac hypertrophy also through …
A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition
T Cheng, C Liu, Y Wang, G Li, L Feng, S Zhang… - Toxicology and Applied …, 2024 - Elsevier
… Therefore, we hypothesized that Se-SAHA was effective at suppressing autophagy and …
is a novel pan-HDAC inhibitor for the treatment of cardiac hypertrophy and fibrosis during …
is a novel pan-HDAC inhibitor for the treatment of cardiac hypertrophy and fibrosis during …
Mechanism of histone deacetylases in cardiac hypertrophy and its therapeutic inhibitors
Y Han, J Nie, DW Wang, L Ni - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
… –131), decreasing overactive autophagy (132), and upregulating … related signaling pathways
are suppressed, and cardiac … and briefly introduce therapeutic HDAC inhibition (Figure 1). …
are suppressed, and cardiac … and briefly introduce therapeutic HDAC inhibition (Figure 1). …
Therapeutic effects of histone deacetylase inhibitors on heart disease
P Chun - Archives of Pharmacal Research, 2020 - Springer
… , and regulation of apoptosis, autophagy, and cell cycle arrest. … cardiac hypertrophy,
hypertension, myocardial infarction, … , leading to the suppression of cardiac hypertrophy induced …
hypertension, myocardial infarction, … , leading to the suppression of cardiac hypertrophy induced …
… alleviates ventricular remodeling in experimental dilated cardiomyopathy via inhibition of NLRP3 inflammasome activation and promotion of cardiomyocyte autophagy
X Pang, Q Guan, X Lin, N Chang - Cell Biology and Toxicology, 2023 - Springer
… cardiomyocyte autophagy and suppressed NLRP3 … Unlike other HDACs, histone deacetylase
6 (HDAC6) contains … cardiomyocyte autophagy, thereby attenuating ventricular remodeling …
6 (HDAC6) contains … cardiomyocyte autophagy, thereby attenuating ventricular remodeling …
Function of histone methylation and acetylation modifiers in cardiac hypertrophy
J Qin, N Guo, J Tong, Z Wang - Journal of molecular and cellular cardiology, 2021 - Elsevier
… Histone acetylation is a reversible modification status … through activation of autophagy,
inhibition of acetylation, suppression of … HDAC inhibitors have been extensively explored for their …
inhibition of acetylation, suppression of … HDAC inhibitors have been extensively explored for their …
HDAC inhibitors as antifibrotic drugs in cardiac and pulmonary fibrosis
X Lyu, M Hu, J Peng, X Zhang… - … advances in chronic …, 2019 - journals.sagepub.com
… that HDAC inhibition can induce histone deacetylation at a … of heart failure; suppression of
HDAC3 improved cardiac … shown to attenuate cardiac hypertrophy and myocardial fibrosis. It is …
HDAC3 improved cardiac … shown to attenuate cardiac hypertrophy and myocardial fibrosis. It is …
HDAC inhibition as a therapeutic strategy in myocardial ischemia/reperfusion injury
… , inhibition of histone deacetylase (HDAC) … II HDAC inhibitors induce autophagy. It has been
demonstrated that TSA reduces transverse aortic banding-induced cardiac hypertrophy [37]. …
demonstrated that TSA reduces transverse aortic banding-induced cardiac hypertrophy [37]. …
The role of histone deacetylases in cardiac energy metabolism in heart diseases
Q Yu, G Zhao, J Liu, Y Peng, X Xu, F Zhao, Y Shi, C Jin… - Metabolism, 2023 - Elsevier
… Finally, we discuss the application of HDAC inhibitors in heart … Mechanistically, Sirt3 could
reduce cardiac hypertrophy by … PPARα, thereby suppressing FA utilization in the failing heart. (…
reduce cardiac hypertrophy by … PPARα, thereby suppressing FA utilization in the failing heart. (…
Histone deacetylase inhibitors for cardiovascular conditions and healthy longevity
JP Ferreira, B Pitt, F Zannad - The Lancet Healthy Longevity, 2021 - thelancet.com
… The use of valproic acid led to attenuated cardiac hypertrophy and fibrosis in these rats. …
-inflammatory and antifibrotic effects is the suppression of profibrotic factors (TGFβ, fibronectin, …
-inflammatory and antifibrotic effects is the suppression of profibrotic factors (TGFβ, fibronectin, …