… Here, we summarize the mechanisms of HDACs and the HDACIs in several cancers. An …
available data on mechanisms and pathways of HDACs and HDACIs in different cancers. The …

… Histone deacetylase inhibitors treatment is often accompanied by oxidative stress related
DNA damage that is primarily caused by the generation of reactive oxygen species (ROS) (Xu …

… The activities of HDACs correspond to chromatin formation, histone acetylation modulation,
and the altering of transcription factors involved in the promoter regions of genes. Cancer is …

… targets in cancer therapy. As a novel category of antitumor agents, histone deacetylase inhibitors
(HDACis… in cancer cells, ultimately combating cancer. Although in the United States, the …

… Histone deacetylase inhibitors (HDIs) are a group of potent epigenetic drugs which have
been investigated for their therapeutic … Currently, several HDIs are already in clinical use and …

… field that targets the epigenome of cancer cells. Histone deacetylase inhibitors (HDACi) and
… drug candidates with the ability to target the epigenome of cancer cells. Although the clinical …

… Gemcitabine synergizes with the histone deacetylase inhibitor MGCD0103 and they
might be an effective treatment for gemcitabine-refractory pancreatic cancer [151]. …

… , histone deacetylase inhibitors (HDACis) are powerful drugs, with some already approved
for certain hematological cancers… NAD + -dependent histone deacetylases similar to the silent …

… Surprisingly, in triple-negative breast cancer cells wherein p53 is mutated and its function
is impaired, the histone deacetylase inhibitors (HDACi) were found to induce H2A.Z …

… Jian at the European Society of Medical Oncology (ESMO) congress this year – A … histone
deacetylase inhibitor, in combination with exemestane in patients with advanced breast cancer …