… signatures predicting 6-month treatment outcome (TB cure vs. treatment failure) and baseline
signatures predicting 2-month treatment outcome (early responders vs. late responders/non…

… The third 58-gene set included type 1-interferon-inducible genes (21) known to be up-regulated
in adult TB and genes associated with prediction of TB risk in South African neonates (29…

… In particular, several mRNA signatures identified in blood transcriptomic studies have …
host blood transcriptional signatures to identify predictive biomarkers for the progression to TB…

… The signature could also be applied for tuberculosis … Screening a 371-gene biosignature
from patients’ blood samples with … host-derived biomarkers in predicting tuberculosis treatment …

… of host blood transcriptomic signatures for diagnosis of and prediction of progression to
Tuberculosis disease… host blood mRNA signatures for diagnosis of or prediction of progression to …

… current study was to identify a blood transcriptional gene signature to predict TB treatment
… Host gene biomarker profiles to identify TB treatment success or failure could facilitate the …

… determined for the TB group was 84.2% (SD, 17.2), and the lowest predicted probability was
… Of note, all 4 members of the TB signature constitute highly accurate individual biomarkers …

… While several published studies have made genome-scale measurements of the in vivo
host response to M.tb at several time points in mice 27,28,29 , none have addressed the …

… Finally, 7 of 16 gene signatures predicted progression from LTBI to ATB 6 months prior to
sputum conversion with positive predictive value > 6% at 2% prevalence. Our analyses may …

… This binary predicted result was then compared to the observed case or control status to …
the activation of these components of host immunity in early TB disease. Of note however, the …