… We review the explanatory–pragmatic distinction in clinical trial design. We use the
PRECIS-2 tool to evaluate the trial design of selected RCTs on percutaneous vertebroplasty for …

… study of 616 cardiovascular randomized clinical trials, the level of pragmatism assessed by
the Pragmatic Explanatory … of cardiovascular trials that are required for broader application of …

… apply to both explanatory trials and pragmatic trials, they require even more care in … use of
these tools, continued learning after initial training, and a standardized practice improvement …

… interest in the use of pragmatic randomised controlled trials (RCTs) … Pragmatic RCTs, in
contrast to explanatory RCTs, aim to … enhanced generalisability to real-world clinical practice [6]. …

… rise in the number of randomised clinical trials (RCTs) being … (an enhanced level of observation
being provided in both trial … Of course, the use of expertise-based pragmatic clinical trials …

… literature on pragmatic randomized controlled trials (RCTs). The … of Medicine, are explanatory
trials that use placebo controls. In … She states, “in cases where enhanced social value is …

… synthesise findings from randomised controlled trials (RCTs) … If you wish to reuse any or all
of this article please use the … led to a statistically significant improvement in odds of adherence …

… first study to systematically evaluate the pragmatism of trials … Most randomized controlled
trials were rated as explanatory (… clinical context of the trial (eg, restricting prior DMARD use in a …

… pragmatism/explanatory continuum of randomized controlled … it, can help to guide the
improvement of quality of care. … use of PRECIS-2 may be another limitation of this study. Indeed, …

… The majority of cardiovascular randomized controlled trials (… in routine clinical settings or if
any improvement in cardiovascular … characteristics of explanatory and pragmatic RCTs across …