… of explanatory and pragmatic trials and … for improvement. The development of guidance
documents have proved a useful resource in improving the rigour of randomised controlled trials …

… and control groups. In line with our findings, a recent adherence-enhancing intervention …
The higher use of statins in our population could be attributed to the strict routine post-ACS …

… randomized controlled trails for two drugs for patients infected with COVID-19 early in the
pandemic, we found that most trials had more pragmatic than explanatory … clinical improvement …

… A specific measure of engagement with education at the 12 month follow-up was included
in the current study that Briskman et al. did not use. This was included as supporting children’s …

… an enhanced EHR alert (Best Practice Advisory [BPA] in Epic®). This alert provides information
about risks of continued medication use and … Pragmatic explanatory continuum indicator …

… Our approach is unique in that we use an implementation … the line between pragmatic and
explanatory trials is not always … effort to identify areas for improvement before the study’s end. …

… engagement and do not commonly use PROs as primary outcomes. … that there is room for
improvement to accomplish this. … Pragmatic randomized controlled trials (RCTs) aim to inform …

… pragmatic randomized controlled trials with at least 100 individuals (excluding pilot or feasibility
studies… similar considerations to apply in pragmatic trials in other clinical areas, involving …

… enhancing patient engagement and addressing diversity in … clinical trials and the application
of research findings. … in more explanatory randomized control trials [98]. In this context, a …

… clinical guidelines that underpin the use of drugs for mental disorders are informed by evidence
from randomised controlled trials (… helps to design explanatory and pragmatic RCTs by …