… anionic nucleic acids such as plasmid DNA (pDNA) or small-interfering RNA (siRNA). As an
… polyplex stability, efficient uptake, endosomal escape, and cargo release into the cytosol is …

… drugs mainly focuses on plasmid DNA (pDNA), messenger … that of lipoplexes formed by
DOTAP/DOPE and siRNA tends to … , the cargo easily leaks from the CP-siRNA complexes due to …

… displayed great siRNA encapsulation and delivery efficiency [61]… Recent studies have reported
the direct fusion of lipoplexes (… location-dependent, but cargo (DNA) size-independent (21 …

… After several attempts to reduce the charges of lipoplexes [14,15… have been used to
encapsulate siRNA or DNA in nanogels. These nanogels obtained by ionic gelation allow an efficient …

… subsequent intracellular processing of the internalized cargo. To explore siRNA delivery in
light of these … Previous studies regarding the cellular uptake of lipoplexes have reported that …

… or plasmid DNA (pDNA) in tumor xenograft of immunodeficient … For lipoplex characterization,
50 µL of siRNA solution … led to enhanced nonspecific delivery of the cargo [2]. Mice were …

… cargo … DNA and works in the cytosol, whereas DNA needs to be transported into the nucleus
for transcription. Upon fusion of siRNA lipoplexes with the plasma membrane, some siRNA …

… mutations associated with DNA therapies.5 Because naked … to siRNA, mixing temperature,
etc.) has led to efficient delivery … interaction between the nanoparticle cargo and the immune …

… , have a significant impact on fusion efficiency in our models. … focus on cationic lipid-DNA
based vectors, called lipoplexes. … the lipoplex cargo, short fragments of double-stranded DNA (…

… have shown that for the same +/− charge ratio, siRNA lipoplexes are not smaller than plasmid
DNA lipoplexes… the impact of adding alginate to lipoplexes by premixing it with siRNAs. We …