Optimizing pDNA lipo-polyplexes: a balancing act between stability and cargo release
S Berger, A Krhač Levačić, E Hörterer… - …, 2021 - ACS Publications
… anionic nucleic acids such as plasmid DNA (pDNA) or small-interfering RNA (siRNA). As an
… polyplex stability, efficient uptake, endosomal escape, and cargo release into the cytosol is …
… polyplex stability, efficient uptake, endosomal escape, and cargo release into the cytosol is …
Assembly strategy of liposome and polymer systems for siRNA delivery
H Song, SL Hart, Z Du - International journal of pharmaceutics, 2021 - Elsevier
… drugs mainly focuses on plasmid DNA (pDNA), messenger … that of lipoplexes formed by
DOTAP/DOPE and siRNA tends to … , the cargo easily leaks from the CP-siRNA complexes due to …
DOTAP/DOPE and siRNA tends to … , the cargo easily leaks from the CP-siRNA complexes due to …
Synthetic approaches for nucleic acid delivery: choosing the right carriers
… displayed great siRNA encapsulation and delivery efficiency [61]… Recent studies have reported
the direct fusion of lipoplexes (… location-dependent, but cargo (DNA) size-independent (21 …
the direct fusion of lipoplexes (… location-dependent, but cargo (DNA) size-independent (21 …
Viscous core liposomes increase siRNA encapsulation and provides gene inhibition when slightly positively charged
… After several attempts to reduce the charges of lipoplexes [14,15… have been used to
encapsulate siRNA or DNA in nanogels. These nanogels obtained by ionic gelation allow an efficient …
encapsulate siRNA or DNA in nanogels. These nanogels obtained by ionic gelation allow an efficient …
Endocytosis controls siRNA efficiency: implications for siRNA delivery vehicle design and cell-specific targeting
… subsequent intracellular processing of the internalized cargo. To explore siRNA delivery in
light of these … Previous studies regarding the cellular uptake of lipoplexes have reported that …
light of these … Previous studies regarding the cellular uptake of lipoplexes have reported that …
Folate-equipped cationic liposomes deliver anti-mdr1-sirna to the tumor and increase the efficiency of chemotherapy
DV Gladkikh, AV Sen′ kova, IV Chernikov… - Pharmaceutics, 2021 - mdpi.com
… or plasmid DNA (pDNA) in tumor xenograft of immunodeficient … For lipoplex characterization,
50 µL of siRNA solution … led to enhanced nonspecific delivery of the cargo [2]. Mice were …
50 µL of siRNA solution … led to enhanced nonspecific delivery of the cargo [2]. Mice were …
Lipoplex-based therapeutics for effective oligonucleotide delivery: a compendious review
P Pal Singh, V Vithalapuram, S Metre… - Journal of Liposome …, 2020 - Taylor & Francis
… cargo … DNA and works in the cytosol, whereas DNA needs to be transported into the nucleus
for transcription. Upon fusion of siRNA lipoplexes with the plasma membrane, some siRNA …
for transcription. Upon fusion of siRNA lipoplexes with the plasma membrane, some siRNA …
Targeted delivery of siRNA lipoplexes to cancer cells using macrophage transient horizontal gene transfer
… mutations associated with DNA therapies.5 Because naked … to siRNA, mixing temperature,
etc.) has led to efficient delivery … interaction between the nanoparticle cargo and the immune …
etc.) has led to efficient delivery … interaction between the nanoparticle cargo and the immune …
A molecular view on the escape of lipoplexed DNA from the endosome
… , have a significant impact on fusion efficiency in our models. … focus on cationic lipid-DNA
based vectors, called lipoplexes. … the lipoplex cargo, short fragments of double-stranded DNA (…
based vectors, called lipoplexes. … the lipoplex cargo, short fragments of double-stranded DNA (…
Modifying internal organization and surface morphology of siRNA lipoplexes by sodium alginate addition for efficient siRNA delivery
DC Arruda, IJ Gonzalez, S Finet, L Cordova… - Journal of colloid and …, 2019 - Elsevier
… have shown that for the same +/− charge ratio, siRNA lipoplexes are not smaller than plasmid
DNA lipoplexes… the impact of adding alginate to lipoplexes by premixing it with siRNAs. We …
DNA lipoplexes… the impact of adding alginate to lipoplexes by premixing it with siRNAs. We …