… as a promising therapeutic target to sensitize cancer cells to … that HuR facilitates radiation
resistance in triple negative … First, we silenced HuR by transfecting with a small interfering …

… expression has been associated with therapy resistance of TNBCs, and obstructing HuR
signaling re-sensitizes TNBC toward chemo-as well as radiotherapies (Citation29, Citation37). …

… H (1996) Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. …
) HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative …

… are mainly associated with DNA damage response, cell death, … and invasion and sensitizes
breast cancer cells to IR. … the expression of those that elicit radiosensitivity are evident …

… HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative …
gene in human colon cancer cells under oxidative stress. Mol Cell Biol 2014;34:2857-73 …

… ’ mRNA, the human antigen R (HuR) has been shown as a … gene silencing of HuR in human
melanoma (MeWo, A375) and normal melanocyte cells in vitro. Cells were treated with HuR …

… Furthermore, HuR silencing also activates caspase3 and … ARID1A sensitizes tumor cells to
cisplatin [53] and that HuR can … Additionally, HuR knockdown reduced DNA repair proteins …

… Finally, 15,16-Dihydrotanshinone-I (DHTS), a HuR inhibitor, successfully sensitized cells
to … DNA damage may induce cytosolic translocation of HuR via activation of the damage …

… or silencing of HuR in human keratinocyte HaCaT cells … HuR facilitates radiation resistance
in triple-negative breast cancer (TNBC) by protecting against radiation-induced DNA damage …

… Understanding HuR-regulatory circuits is further complicated … as HuR but generally elicit
antagonistic outputs to HuR binding. … reports of the sensitivity of HuR to oxidative stress (64), we …