Natural killer cell defects in breast cancer: a key pathway for tumor evasion
E Arianfar, S Shahgordi, A Memarian - International reviews of …, 2021 - Taylor & Francis
… called “non-self recognition”; (c) over-expression of self-proteins in … NK cell activation and
promotes antibody-dependent cell-… could frustrate NK cell antitumor activity in patients with BC. …
promotes antibody-dependent cell-… could frustrate NK cell antitumor activity in patients with BC. …
[HTML][HTML] Killing the invaders: NK cell impact in tumors and anti-tumor therapy
… function and overcome tumor evasion. The characterization … NK self-reactivity and promotes
NK cell activation against … advanced mammary tumors. Furthermore, defective expression of …
NK cell activation against … advanced mammary tumors. Furthermore, defective expression of …
[HTML][HTML] Underlying mechanisms of evasion from NK cells as rationale for improvement of NK cell-based immunotherapies
… breast cancer, chronic lymphocytic leukemia (CLL), ovarian … escape or immune recognition.
Characterization of these … Since NK cell anti-tumor function is frequently impaired in tumor …
Characterization of these … Since NK cell anti-tumor function is frequently impaired in tumor …
[HTML][HTML] Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance
VM Knab, D Gotthardt, K Klein, R Grausenburger… - Cell Death & …, 2021 - nature.com
… To gain insights into how CDK8 promotes the metastatic potential of murine TNBC, we …
evidence that in addition to T cells, NK cells contribute to the promising antitumor effects of PD-1/…
evidence that in addition to T cells, NK cells contribute to the promising antitumor effects of PD-1/…
NK cells-directed therapies target circulating tumor cells and metastasis
… Immune evaded primary tumor cells detached under EMT in … , which they sensitize CTC to
NK cell antitumor effects [41]. In … HER2-positive breast cancer cells are more aggressive and …
NK cell antitumor effects [41]. In … HER2-positive breast cancer cells are more aggressive and …
[HTML][HTML] Mechanisms of apoptosis resistance to NK cell-mediated cytotoxicity in cancer
C Sordo-Bahamonde, S Lorenzo-Herrero… - International journal of …, 2020 - mdpi.com
… cancer cells from diverse solid tumors, such as breast cancer… )-mediated immune suppression,
dampening antitumor NK cell … conditions in tumor evasion of NK cell responses [243,244]. …
dampening antitumor NK cell … conditions in tumor evasion of NK cell responses [243,244]. …
From the “missing self” hypothesis to adaptive NK cells: Insights of NK cell-mediated effector functions in immune surveillance
ME Cruz-Muñoz, L Valenzuela-Vázquez… - Journal of Leukocyte …, 2019 - academic.oup.com
… DNAM promotes NK cell activation via an immunoreceptor … cancer cells may be a mechanism
to evade antitumor NK cell-… allogeneic NK cells to fight ovarian and breast cancer led to …
to evade antitumor NK cell-… allogeneic NK cells to fight ovarian and breast cancer led to …
[HTML][HTML] Exploiting NK cell surveillance pathways for cancer therapy
… or cellular transformation (termed ‘induced self recognition’) [11]. … or cancer cells that have
downregulated MHC-I to evade … Moreover, there is evidence that NKG2D mediates anti-cancer …
downregulated MHC-I to evade … Moreover, there is evidence that NKG2D mediates anti-cancer …
[HTML][HTML] Natural killer cells in cancer biology and therapy
SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
… evade CD8 + T cell-mediated cytotoxicity, whereas licensed … use of NK cells as anti-cancer
agents. In addition, unlicensed … for promoting NK cell-induced cytotoxicity toward cancer. As …
agents. In addition, unlicensed … for promoting NK cell-induced cytotoxicity toward cancer. As …
Mechanism of tumor cells escaping from immune surveillance of NK cells
Z Ge, S Wu, Z Zhang, S Ding - Immunopharmacology and …, 2020 - Taylor & Francis
… from spleen may indicate immune tolerance and favor tumor … cells, thereby allowing tumor
cells to evade NK cell immune … NK cell exhaustion and restore the anti-tumor immunity of …
cells to evade NK cell immune … NK cell exhaustion and restore the anti-tumor immunity of …