Transcriptomic insight into cadmium-induced neurotoxicity in embryonic neural stem/progenitor cells

P Deng, Q Ma, Y Xi, L Yang, M Lin, Z Yu, C Chen… - Toxicology in Vitro, 2020 - Elsevier
… The neurotoxicity of cadmium has been extensively … development and has also been
detected in milk during lactation (Korpela et al., 1986). Therefore, the developmental neurotoxicity (…

Classification of developmental toxicants in a human iPSC transcriptomics-based test

A Cherianidou, F Seidel, F Kappenberg… - Chemical Research …, 2022 - ACS Publications
… For the UKK2 test system, the cells were cultured and maintained in StemMACS iPS-Brew
XF medium (Miltenyi Biotec, Germany) on plates coated with Matrigel (Corning GmbH, …

Developmental neurotoxicity in a human model system

S Klima - 2021 - kops.uni-konstanz.de
… A human stem cell-derived test system for agents modifying … -based test systems differed
strongly in their transcriptome re… on altered transcriptome patterns in developmental toxicity …

[PDF][PDF] Impact of environmental neurotoxic: current methods and usefulness of human stem cells

A Rosca, R Coronel, M Moreno, R González, A Oniga… - Heliyon, 2020 - cell.com
… study developmental neurotoxicity and review in more detail the usefulness of human stem
cells, … The criteria were clustered into 13 groups concerning to test system, exposure scheme, …

Human pluripotent stem cells as tools for predicting developmental neural toxicity of chemicals: strategies, applications, and challenges

S Liang, N Yin, F Faiola - Stem Cells and Development, 2019 - liebertpub.com
Human embryonic stem cell-derived GABA neurons correct locomotion deficits in … Human
embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics ap…

… efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity

VC de Leeuw, CTM van Oostrom, RHS Westerink… - Reproductive …, 2020 - Elsevier
Human embryonic stem cell neuronal differentiation models … developmental neurotoxicity
of chemicals. Such models mimic essential elements of human relevant neuronal development, …

… analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system

S Liang, S Liang, N Yin, B Hu, F Faiola - Toxicology and Applied …, 2019 - Elsevier
… , we induced human embryonic stem cells to differentiate into neural ectoderm in the … Human
embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics

Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies

VBR Konala, S Nandakumar, H Surendran… - Toxicology and Applied …, 2021 - Elsevier
test systems are costly, tedious, and cannot always translate into human developmental
published reports showing cardiovascular anomalies and neurotoxic defects in chick model as a …

[HTML][HTML] Human induced pluripotent stem cell-derived 3D-neurospheres are suitable for neurotoxicity screening

J Kobolak, A Teglasi, T Bellak, Z Janstova, K Molnar… - Cells, 2020 - mdpi.com
… both for NT and developmental neurotoxicology (DNT) tests, … efficient, highly reproducible
neurotoxicology test system, an … from the media or terminal transcriptomic or proteomic assays, …

Human Embryonic Stem Cells as a Predictive Model for Developmental Toxicity and Disease: Reducing the Use of Animal Testing in Regulatory Toxicology

T Eng - 2023 - ruor.uottawa.ca
… using human embryonic stem cells (hESCs) for environmental chemicals. In this study, hESCs
were exposed to three known developmental … for their full transcriptome. Gene expression …