Transcriptomic insight into cadmium-induced neurotoxicity in embryonic neural stem/progenitor cells
P Deng, Q Ma, Y Xi, L Yang, M Lin, Z Yu, C Chen… - Toxicology in Vitro, 2020 - Elsevier
… The neurotoxicity of cadmium has been extensively … development and has also been
detected in milk during lactation (Korpela et al., 1986). Therefore, the developmental neurotoxicity (…
detected in milk during lactation (Korpela et al., 1986). Therefore, the developmental neurotoxicity (…
Classification of developmental toxicants in a human iPSC transcriptomics-based test
A Cherianidou, F Seidel, F Kappenberg… - Chemical Research …, 2022 - ACS Publications
… For the UKK2 test system, the cells were cultured and maintained in StemMACS iPS-Brew
XF medium (Miltenyi Biotec, Germany) on plates coated with Matrigel (Corning GmbH, …
XF medium (Miltenyi Biotec, Germany) on plates coated with Matrigel (Corning GmbH, …
Developmental neurotoxicity in a human model system
S Klima - 2021 - kops.uni-konstanz.de
… A human stem cell-derived test system for agents modifying … -based test systems differed
strongly in their transcriptome re… on altered transcriptome patterns in developmental toxicity …
strongly in their transcriptome re… on altered transcriptome patterns in developmental toxicity …
[PDF][PDF] Impact of environmental neurotoxic: current methods and usefulness of human stem cells
A Rosca, R Coronel, M Moreno, R González, A Oniga… - Heliyon, 2020 - cell.com
… study developmental neurotoxicity and review in more detail the usefulness of human stem
cells, … The criteria were clustered into 13 groups concerning to test system, exposure scheme, …
cells, … The criteria were clustered into 13 groups concerning to test system, exposure scheme, …
Human pluripotent stem cells as tools for predicting developmental neural toxicity of chemicals: strategies, applications, and challenges
S Liang, N Yin, F Faiola - Stem Cells and Development, 2019 - liebertpub.com
… Human embryonic stem cell-derived GABA neurons correct locomotion deficits in … Human
embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics ap…
embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics ap…
… efficient neuron-astrocyte differentiation protocol from human embryonic stem cell-derived neural progenitors to assess chemical-induced developmental neurotoxicity
VC de Leeuw, CTM van Oostrom, RHS Westerink… - Reproductive …, 2020 - Elsevier
… Human embryonic stem cell neuronal differentiation models … developmental neurotoxicity
of chemicals. Such models mimic essential elements of human relevant neuronal development, …
of chemicals. Such models mimic essential elements of human relevant neuronal development, …
… analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation system
S Liang, S Liang, N Yin, B Hu, F Faiola - Toxicology and Applied …, 2019 - Elsevier
… , we induced human embryonic stem cells to differentiate into neural ectoderm in the … Human
embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics …
embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics …
Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies
VBR Konala, S Nandakumar, H Surendran… - Toxicology and Applied …, 2021 - Elsevier
… test systems are costly, tedious, and cannot always translate into human developmental …
published reports showing cardiovascular anomalies and neurotoxic defects in chick model as a …
published reports showing cardiovascular anomalies and neurotoxic defects in chick model as a …
[HTML][HTML] Human induced pluripotent stem cell-derived 3D-neurospheres are suitable for neurotoxicity screening
… both for NT and developmental neurotoxicology (DNT) tests, … efficient, highly reproducible
neurotoxicology test system, an … from the media or terminal transcriptomic or proteomic assays, …
neurotoxicology test system, an … from the media or terminal transcriptomic or proteomic assays, …
Human Embryonic Stem Cells as a Predictive Model for Developmental Toxicity and Disease: Reducing the Use of Animal Testing in Regulatory Toxicology
T Eng - 2023 - ruor.uottawa.ca
… using human embryonic stem cells (hESCs) for environmental chemicals. In this study, hESCs
were exposed to three known developmental … for their full transcriptome. Gene expression …
were exposed to three known developmental … for their full transcriptome. Gene expression …