Full article: Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in
smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers …

… In this study, we characterized the total miRNA profile of circulating sEVs enriched … small
RNA libraries, a total amount of 2.5ng RNA per sample was used as input material for the RNA …

… small RNA-seq technology to profile exosomal tsRNAs from cell culture medium and plasma,
… could be incorporated into exosomes and secreted into extracellular environment (Fig. 1d). …

… blood and contain molecule markers of their … small EVs (NDEVs) and their micro RNA (miRNA)
cargo in Alzheimer’s disease (AD) patients. Small NDEVs were isolated from plasma in a …

… of the resulting small RNA-seq profiles. The relative … extracellular RNAs (exRNAs) in
biofluids has sparked considerable interest in their biological functions and potential clinical …

… of CCA, but their low sensitivity (particularly in … their clinical utility [7,10]. Therefore, tumor
biopsy is currently mandatory to confirm the diagnosis and staging of CCA, guiding the clinical …

… -seq expression profiles from 501 human plasma EV samples representing, to our knowledge,
the largest published long RNA-seq expression profile library from human plasma EVs. In …

… While sequencing of small RNAs 3 and targeted or capture sequencing … RNA cargo filling
of extracellular vesicles. Here, we compared RNA abundance profiles between EVs and their …

… , including whole blood, blood cells and extracellular vesicles… of analytical validity, clinical
validity and clinical utility (Byron et al… , gene expression profiles of PBMCs or whole blood have …

… profile associated to plasma-derived EVs from DLB, AD and healthy controls. We further
investigated whether differences in the plasma-EV-… of the purified small RNA was assessed by …