[HTML][HTML] Engineered recombinant single chain variable fragment of monoclonal antibody provides protection to chickens infected with H9N2 avian influenza

D Lukosaityte, JR Sadeyen, A Shrestha, JE Sealy… - Vaccines, 2020 - mdpi.com
neutralizing anti-H9N2 virus monoclonal antibodies were … immunogenicity in heterologous
species and for use in … diluted live H9N2 viruses of different strains probed with a constant …

[HTML][HTML] Human CD4-binding site antibody elicited by polyvalent DNA prime-protein boost vaccine neutralizes cross-clade tier-2-HIV strains

S Wang, KW Chan, D Wei, X Ma, S Liu, G Hu… - Nature …, 2024 - nature.com
… HmAb64 was also able to bind to other unrelated (heterologous) gp120 antigens, though …
We, therefore, produced a single chain variable fragment (scFv) of HmAb64 and used it to form …

[PDF][PDF] Antibody lineages with vaccine-induced antigen-binding hotspots develop broad HIV neutralization

R Kong, H Duan, Z Sheng, K Xu, P Acharya, X Chen… - Cell, 2019 - cell.com
… lineage neutralized 59% of a cross-clade panel of 208 strains, … FP-directed cross-clade
neutralizing Abs of >50% breadth. … variants neutralized none of the 9 heterologous viruses tested …

Development of antibody therapeutic approaches for poultry diseases using avian influenza as a disease model

D Lukosaityte - 2022 - era.ed.ac.uk
… were evaluated against homologous and heterologous … natural antibody isotype after
conversion to single chain variable … were evaluated against an array of different H9N2 AIV strains

Neutralizing monoclonal antibodies against highly pathogenic coronaviruses

R Xiang, Y Wang, L Wang, X Deng, S Huo… - Current Opinion in …, 2022 - Elsevier
… The 3B11 was screened from a nonimmune phage-displayed single chain … problem of
heterologous single-domain antibodies, … neutralizing activity against clade 1 sarbecoviruses [72]. …

[PDF][PDF] Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

E Seydoux, YH Wan, J Feng, A Wall, S Aljedani… - Cell reports, 2021 - cell.com
… generated through homology-guided reversion of antibody … VRC01 precursor that bound a
heterologous germline-targeting … 20 mg/mL of purified human antibody for a 100 s association …

Strategies for inducing effective neutralizing antibody responses against HIV-1

I del Moral-Sánchez, K Sliepen - Expert review of vaccines, 2019 - Taylor & Francis
… did not show neutralizing activity against heterologous Tier 2 … between gp120 and gp41
('single-chain' or 'native flexibly … a clade C Env trimer could cross-boost responses to clade A …

[HTML][HTML] Virus-like particle based vaccines elicit neutralizing antibodies against the HIV-1 fusion peptide

AT Mogus, L Liu, M Jia, DT Ajayi, K Xu, R Kong… - Vaccines, 2020 - mdpi.com
… protein single-chain dimers have been engineered for genetic insertion of heterologous
DS-SOSIP), had the strongest neutralizing activity against prototype Clade A and B HIV-1 virus …

[HTML][HTML] Recent progress in the discovery and development of monoclonal antibodies against viral infections

P Mokhtary, Z Pourhashem, AA Mehrizi, C Sala… - Biomedicines, 2022 - mdpi.com
… to nanobodies, ie, single-chain antibodies consisting of a … against a heterologous simian/human
immunodeficiency virus … for flaws in an antibody homology model that would otherwise …

[HTML][HTML] Kappa chain maturation helps drive rapid development of an infant HIV-1 broadly neutralizing antibody lineage

CA Simonich, L Doepker, D Ralph, JA Williams… - Nature …, 2019 - nature.com
… We also show that heterologous cross-clade neutralizinghomology models, the contacts
are less certain for this loop. … was a single-chain variant of anti-gp120 antibody, b12 (PDB ID:…