[HTML][HTML] VEGF-A and blood vessels: a beta cell perspective
W Staels, Y Heremans, H Heimberg, N De Leu - Diabetologia, 2019 - Springer
… of the role of vascular endothelial growth factor-A (VEGF-A) and endothelial cells in beta cell
… Overexpression of VEGF-A in developing beta cells results in reduced beta cell proliferation …
… Overexpression of VEGF-A in developing beta cells results in reduced beta cell proliferation …
[HTML][HTML] The aging vasculature: glucose tolerance, hypoglycemia and the role of the serum response factor
H Aberdeen, K Battles, A Taylor… - Journal of …, 2021 - mdpi.com
… reported vascular endothelial growth factor (… hypoglycemic episodes more difficult for clinical
specialists [111]. In the elderly, the threshold of symptoms of hypoglycemia occurs at lower …
specialists [111]. In the elderly, the threshold of symptoms of hypoglycemia occurs at lower …
Targeting the pancreatic α-cell to prevent hypoglycemia in type 1 diabetes
… molecules strongly inhibits glucagon secretion in response to decreases in glucose concentration
(31). Thus, the α-cell response to hypoglycemia relies on redundant positive feedback. …
(31). Thus, the α-cell response to hypoglycemia relies on redundant positive feedback. …
Hypoglycemia induces mitochondrial reactive oxygen species production through increased fatty acid oxidation and promotes retinal vascular permeability in diabetic …
A Yoshinaga, N Kajihara, D Kukidome… - Antioxidants & Redox …, 2021 - liebertpub.com
… reduced mtROS production, reduced vascular endothelial growth factor (VEGF) production
during hypoglycemia… and growth factors, including vascular endothelial growth factor (VEGF), …
during hypoglycemia… and growth factors, including vascular endothelial growth factor (VEGF), …
Placental growth factor in beta cells plays an essential role in gestational beta-cell growth
… . Hypoglycemia reduces vascular endothelial growth factor A production by pancreatic
beta cells as a regulator of beta cell mass. J Biol Chem 2013;288:8636–46.doi:10.1074/jbc.M112.…
beta cells as a regulator of beta cell mass. J Biol Chem 2013;288:8636–46.doi:10.1074/jbc.M112.…
Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications
E Papachristoforou, V Lambadiari… - Journal of diabetes …, 2020 - Wiley Online Library
… the production of the vascular endothelial growth factor (… -induced beta cell dysfunction by
decreasing intracellular ROS … , reduces blood pressure, and decreases vascular cell adhesion …
decreasing intracellular ROS … , reduces blood pressure, and decreases vascular cell adhesion …
[HTML][HTML] Effects of hypoglycemia on cardiovascular function in patients with diabetes
MA Christou, PA Christou, C Kyriakopoulos… - International Journal of …, 2023 - mdpi.com
… to reduce hypoglycemia and its adverse cardiovascular outcomes in patients with T1D. …
alpha (TNFα), interleukin 1β (IL1β), IL6, IL8, and vascular endothelial growth factor (VEGF) …
alpha (TNFα), interleukin 1β (IL1β), IL6, IL8, and vascular endothelial growth factor (VEGF) …
Extracellular Matrix–Associated Factors Play Critical Roles in Regulating Pancreatic β-Cell Proliferation and Survival
SE Townsend, M Gannon - Endocrinology, 2019 - academic.oup.com
… ECM-localized growth factors, such as vascular endothelial growth factor and cellular … β-cell
area compared with total pancreatic area was reduced to 75% of control levels, and β-…
area compared with total pancreatic area was reduced to 75% of control levels, and β-…
[HTML][HTML] Hypoxia-inducible factors and diabetes
JE Gunton - The Journal of clinical investigation, 2020 - Am Soc Clin Investig
… Lower ATP generation, even when glucose is elevated, … with decreases in expression of
the HIF-1 transcription factor. … A number of hypoglycemic agents may decrease cardiac risk …
the HIF-1 transcription factor. … A number of hypoglycemic agents may decrease cardiac risk …
Recurrent hypoglycemia impaired vascular function in advanced T2DM rats by inducing pyroptosis
M Luo, Y Hu, D Lv, L Xie, S Yang, D Zuo… - … and Cellular …, 2022 - Wiley Online Library
… Hypoglycemia was associated with a marked decrease in vascular function, elevated oxidative
… in rats with recurrent hypoglycemia than in those with acute hypoglycemia. Conclusions. …
… in rats with recurrent hypoglycemia than in those with acute hypoglycemia. Conclusions. …