… : a member of the IκB family of NF-κB inhibitor proteins and the IκB kinase (IKK) complex. …
kinase catalytic activity and instead serves an essential accessory role in activation of NF-κB …

… These kinases are considered master regulators of … described to activate canonical and
noncanonical NF-κB, IKKα … B kinase; IL-1β, interleukin 1β; NEMO, NF-κB essential modulator; …

… Because IKK and IKK related kinases play a crucial role in the NF-κB activation pathway, …
against these kinases for cancer therapy. Since IKKβ is the primary regulator of NF-κB, most …

… In the non-canonical signaling, an NF-κB-inducing kinase (NIK) activates IKKα, which then
… Thus, NF-κB is important for breast tumor development through RANKL/RANK/IKKα to the …

… NF-κB family, along with its inhibitors (IκB family) and activators (IκB kinase complex), work
together to exert important … Therefore, the capabilities of EcIKKα-1 and -2 to activate NF-κB …

… necessary player in immunity, but contributes primarily through an alternative pathway. After
IκBα proteolysis, the NF-κB … into hydrogen bonding distance to IKK’2 N-terminal αC residues, …

… Activation of inhibitor of nuclear factor NF-κB kinase subunit-β (IKKβ), characterized by
phosphorylation of activation … do not indicate when action is needed. Findings from a North …

… However, the IKKα subunit has been shown to be dispensable for NF-κB activation and …
NF-κB essential modulator (NEMO)] [8] , thereby phosphorylating and activating both kinases in …

… may possesses a strongest kinase activity, followed by AbIKK1 and AbIKK2, when stimulated
with cytokines. IKK is an essential protein kinase regulating NF-κB activation in response to …

… -B kinase ε) is a member of the noncanonical NF-κB pathway. It … Ser36) of IκB-α, resulting
in NF-κB activation. Recent studies … but essential for the kinase activity of IKKε. IKKε loses its …