IL-4 augments IL-31/IL-31 receptor alpha interaction leading to enhanced Ccl 17 and Ccl 22 production in dendritic cells: implications for atopic dermatitis
S Miake, G Tsuji, M Takemura… - International journal of …, 2019 - mdpi.com
Severe pruritus is a characteristic feature of atopic dermatitis (AD) and is closely related to its
activity. Recent studies have shown that IL-31 is a key determinant of pruritus in AD. Anti-IL-
31 receptor alpha (IL-31RA) antibody treatment has also been reported to improve pruritus
clinically, subsequently contributing to the attenuation of AD disease activity. Therefore, IL-
31 has been thought to be an important cytokine for regulating pruritus and AD disease
activity; however, how IL-31 is involved in the immune response in AD has remained largely …
activity. Recent studies have shown that IL-31 is a key determinant of pruritus in AD. Anti-IL-
31 receptor alpha (IL-31RA) antibody treatment has also been reported to improve pruritus
clinically, subsequently contributing to the attenuation of AD disease activity. Therefore, IL-
31 has been thought to be an important cytokine for regulating pruritus and AD disease
activity; however, how IL-31 is involved in the immune response in AD has remained largely …
[PDF][PDF] IL-4 Augments IL-31-L-31 Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22 Production in Dendritic-ells: Implications for Atopic Dermatitis
見明彰 - 2020 - catalog.lib.kyushu-u.ac.jp
Severe pruritus is a characteristic feature of atopic dermatitis (AD) and is closely related to its
activity. Recent studies have shown that IL-31 is a key determinant of pruritus in AD. Anti-IL-
31 receptor alpha (IL-31RA) antibody treatment has also been reported to improve pruritus
clinically, subsequently contributing to the attenuation of AD disease activity. Therefore, IL-
31 has been thought to be an important cytokine for regulating pruritus and AD disease
activity; however, how IL-31 is involved in the immune response in AD has remained largely …
activity. Recent studies have shown that IL-31 is a key determinant of pruritus in AD. Anti-IL-
31 receptor alpha (IL-31RA) antibody treatment has also been reported to improve pruritus
clinically, subsequently contributing to the attenuation of AD disease activity. Therefore, IL-
31 has been thought to be an important cytokine for regulating pruritus and AD disease
activity; however, how IL-31 is involved in the immune response in AD has remained largely …
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