IL-6 and IL-8: an overview of their roles in healthy and pathological pregnancies

A Vilotić, M Nacka-Aleksić, A Pirković… - International journal of …, 2022 - mdpi.com
Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic action,
mediating innate and adaptive immunity and multiple physiological processes, including
protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with a primary
function in attracting and activating neutrophils, but also implicated in a variety of other
cellular processes. These two ILs are abundantly expressed at the feto-maternal interface
over the course of a pregnancy and have been shown to participate in numerous pregnancy …

IL-6 and IL-8: An Overview of Their Roles in Healthy and Pathological Pregnancies

A Vilotic, M Nacka-Aleksic, A Pirkovic… - Int. J. Mol. Sci, 2022 - europepmc.org
Abstract Interleukin-6 (IL-6) is an acknowledged inflammatory cytokine with a pleiotropic
action, mediating innate and adaptive immunity and multiple physiological processes,
including protective and regenerative ones. IL-8 is a pro-inflammatory CXC chemokine with
a primary function in attracting and activating neutrophils, but also implicated in a variety of
other cellular processes. These two ILs are abundantly expressed at the feto-maternal
interface over the course of a pregnancy and have been shown to participate in numerous …
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