… and neurological status together with idebenone values and … that primarily affects the
nervous system and the heart. Most … and biochemical data from our cohort of Friedreich’s ataxia (…

… Friedreich ataxia is an autosomal recessive … disorder that principally affects the heart
and the nervous system. … treatments are available for Friedreich ataxia cardiomyopathy…

… Heart complications that occur in FA are treated with … require specialist care and monitoring.
Pharmacological … such as idebenone, vitamin E, coenzyme Q10 on the neurological features …

… along with cardiac MRI to monitor epicatechin administration [… This result was driven by
idebenone studies in combination … on any other clinical, cardiac, biochemical, PROMs, imaging, …

… be used to monitor cardiac disease in this mitochondrial disorder. … with severe cardiomyopathy
in the absence of neurologic … Idebenone has improved cardiomyopathy in a very limited …

… the cardiomyopathy progression and the neurologic impact of … , monitoring biomarkers of
cardiac injury such as cardiac troponin I … impact of idebenone on heart and exercise. Although …

… utilized in both clinical and research settings to monitor … clinical trials with equivocal cardiac
and neurological results. In … significant neurological benefits with higher doses of idebenone …

… should provide a biochemical cure and stabilize disease … no cardiac improvement in
subjects treated with Idebenone … in neurologic function over short time periods, Idebenone did …

… Therefore, the biological function of frataxin still remains … on the neurological or cardiac
function of idebenone in different … neuronal features that are monitored in the clinical scales. In …

… /idebenone has been shown to stabilize neurological status and reduces cardiac … Plasma
concentrations of vitamin E should be monitored every 6 months and should return to normal …