… identified melanocytes as target cells of the psoriatic immune … highlighting the tight
connection of innate and adaptive … as a genetic susceptibility locus for psoriasis and appears to …

… identified in PsA highlights pathways of critical importance to … of psoriasis [14,15]. In this
article we review the genetics of … including the known PsA susceptibility locus TNFAIP3 [32]. …

… a role in disease development, and over 80 susceptibility loci … that may play a role in the
innate immunity of the skin, … highlights the importance of genetic factors in psoriasis and …

… of psoriasis have uncovered >80 psoriasis susceptibility loci … a TWAS to identify genes
associated with psoriasis by … The top panel in each plot highlights all genes in the region. The …

… profiles in psoriasis-affected skin, highlighting roles for the … identified psoriasis susceptibility
loci, we sought to identify … target genes, including many innate immune genes (eg, …

… relevant biological functions in differentiation and innate immunity [… in our data with keratin
15 being the 6th most differentially … Whilst our study was limited in its ability to identify a single …

… identified more than 65 independent genomic risk loci that confer risk of the disease [6,7,8].
These susceptibility loci … involved in specific adaptive and innate immune pathways, such as …

… with concomitant psoriasis vulgaris, but were only rarely identified in … psoriasis, but it is
inclined more towards innate immune … In order to highlight the major cutaneous manifestations of …

… This highlights an advantage of CRISPR-Cas genome engineering, which enables direct …
studies have identified more than 80 genetic loci associated with psoriasis susceptibility, …

… involved in adaptive and innate immunity, and skin barrier function. Many contemporary
studies … Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. …