Prediction of gene cluster function based on transcriptional regulatory networks uncovers a novel locus required for desferrioxamine B biosynthesis
… genome analysis identified the novel desJGH gene cluster. … the putative direct regulon of
DmdR1 from 25 to 155 58 genes, … is showcased in our study of Streptomyces coelicolor M145, a …
DmdR1 from 25 to 155 58 genes, … is showcased in our study of Streptomyces coelicolor M145, a …
Iron-meditated fungal starvation by lupine rhizosphere-associated and extremotolerant Streptomyces sp. S29 desferrioxamine production
SA Jarmusch, D Lagos-Susaeta, E Diab, O Salazar… - Molecular omics, 2021 - pubs.rsc.org
… additional previously described were identified, clearly showing a … (III) is toxic and has no
direct role in metabolism and seems to be … S29 des gene cluster is ongoing to link the chemical …
direct role in metabolism and seems to be … S29 des gene cluster is ongoing to link the chemical …
Biosynthesis of novel desferrioxamine derivatives requires unprecedented crosstalk between separate NRPS-independent siderophore pathways
L Su, Y Souaibou, L Hôtel, C Paris… - Applied and …, 2024 - Am Soc Microbiol
… identified DFO-B and -E, produced by both Streptomyces ambofaciens and mutants obtained
by genetic engineering of the stambomycin gene cluster … to obtain more direct evidence for …
by genetic engineering of the stambomycin gene cluster … to obtain more direct evidence for …
Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus
… biosynthetic gene cluster in S. sviceus and proposed enzymatic steps involved in the synthesis
of desferrioxamine … a higher sequence identity to DesB in the industrial desferrioxamine B-…
of desferrioxamine … a higher sequence identity to DesB in the industrial desferrioxamine B-…
Production and Potential Genetic Pathways of Three Different Siderophore Types in Streptomyces tricolor Strain HM10
… rings (ie, desferrioxamine B/E from Streptomyces griseus and/or S. … to obtain direct comparisons
among treatments’ means. … identified hydroximate desferrioxamine B/E siderophore from …
among treatments’ means. … identified hydroximate desferrioxamine B/E siderophore from …
Biosynthesis of desferrioxamine siderophores initiated by decarboxylases: A functional investigation of two lysine/ornithine-decarboxylases from Gordonia …
M Hofmann, JSM Del Campo, P Sobrado… - Archives of Biochemistry …, 2020 - Elsevier
… to direct the desferrioxamine biosynthesis and some … the desferrioxamine biosynthetic
gene clusters of Streptomyces … The prototypic genes desABCD (first identified in S. coelicolor), …
gene clusters of Streptomyces … The prototypic genes desABCD (first identified in S. coelicolor), …
Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis
… native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high
… The identity and estimates of the relative concentration of constitutional isomers determined …
… The identity and estimates of the relative concentration of constitutional isomers determined …
Siderophore synthetase DesD catalyzes N-to-C condensation in desferrioxamine biosynthesis
J Yang, VS Banas, GSM Rivera… - ACS Chemical …, 2023 - ACS Publications
… Here, we establish the directionality of desferrioxamine biosynthesis using a chemoenzymatic
… a unifying biosynthetic paradigm for desferrioxamine natural products in Streptomyces. …
… a unifying biosynthetic paradigm for desferrioxamine natural products in Streptomyces. …
Blocks in the pseudouridimycin pathway unlock hidden metabolites in the Streptomyces producer strain
M Iorio, S Davatgarbenam, S Serina, P Criscenzo… - Scientific Reports, 2021 - nature.com
… biosynthetic gene clusters were readily identified in the strain … metabolites) and also by
direct analysis of the cleared broth (… of lydicamycins and desferrioxamines were detected in the …
direct analysis of the cleared broth (… of lydicamycins and desferrioxamines were detected in the …
Identification of Novel Rotihibin Analogues in Streptomyces scabies, Including Discovery of Its Biosynthetic Gene Cluster
S Planckaert, B Deflandre, AM De Vries… - Microbiology …, 2021 - Am Soc Microbiol
… sites within the thaxtomin biosynthetic gene cluster (BGC), … In addition, several bld global
regulators directing secondary … in acyl-desferrioxamines of Streptomyces coelicolor (49). …
regulators directing secondary … in acyl-desferrioxamines of Streptomyces coelicolor (49). …