Methyl DNA phosphate adduct formation in lung tumor tissue and adjacent normal tissue of lung cancer patients

B Ma, PW Villalta, JB Hochalter, I Stepanov… - …, 2019 - academic.oup.com
… two structurally unique methyl DNA phosphate adducts were … methyl DNA phosphate adducts
in NNK- and NNAL-treated rats … To date, the detection of methyl DNA phosphate adducts in …

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Y Li, B Ma, Q Cao, S Balbo, L Zhao… - Chemical research in …, 2019 - ACS Publications
… ice-cold 70% ethanol and 100% ethanol sequentially. DNA … of 32 possible structurally
unique DNA phosphate adducts … able to identify up to the maximum 32 unique DNA phosphate

Identification of an N′-Nitrosonornicotine-Specific Deoxyadenosine Adduct in Rat Liver and Lung DNA

Y Li, SS Hecht - Chemical research in toxicology, 2021 - ACS Publications
… Total NNN exposures to the rats from the 50, 100, or 500 ppm groups overadduct level in
rat liver and lung. N 6 -HPB-dAdo is a new and structurally unique type of DNA adduct formed

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

B Ma, I Stepanov, SS Hecht - Toxics, 2019 - mdpi.com
unique DNA phosphate adducts in NNK-treated rats. This is by far the most structurally diverse
panel of DNA adducts identified … 10 to 100-fold higher in the same type of tissues when

Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines

Y Li, SS Hecht - International journal of molecular sciences, 2022 - mdpi.com
unique dGuo adduct formed by NNKOAc has been identifiedDNA phosphate adducts were
quantified using the same rat … of 107 structurally unique PHB DNA phosphate adducts 76 (…

Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism

Y Li, ES Carlson, AT Zarth, P Upadhyaya… - Chemical research in …, 2021 - ACS Publications
adduct panel formed by NNN 5′-hydroxylation and identify … study characterized a structurally
unique dAdo adduct N 6 -… investigating new DNA phosphate adducts formed by NNN 5′-…

Investigating the discriminatory potential of urinary DNA adductomics in smokeless tobacco-treated rats and head-neck cancer patients

SB Jorvekar, S Chouhan, G Narkhede, A Rai, A Das… - Microchemical …, 2024 - Elsevier
… , on the DNA structure by analyzing DNA adduct profiles. This … By identifying the DNA adducts
formed due to carcinogen … statistically significant DNA adducts within three distinct groups: …

Liquid chromatography-mass spectrometry for analysis of DNA damages induced by environmental exposure

J Yin, N Zhang, H Wang - TrAC Trends in Analytical Chemistry, 2019 - Elsevier
… reacts with DNA to give adducts in CD1 male rats. Two major … for the elucidation of adduct
structure. This new approach … they identified up to the maximum 32 unique DNA phosphate

Identification of formaldehyde-induced DNA–RNA cross-links in the A/J mouse lung tumorigenesis model

RP Dator, KJ Murray, MW Luedtke… - Chemical research in …, 2022 - ACS Publications
… We have identified a new class of DNA adducts, DNA–RNA … to the formation of spontaneous
tumors, for instance in rats, the … Here, we have identified and structurally characterized, for …

A comprehensive database for DNA adductomics

G La Barbera, KD Nommesen, C Cuparencu… - Frontiers in …, 2022 - frontiersin.org
… DNA adducts together with the technique used for identification… One unique entry was
associated to each DNA adduct and … ) a lack of structural characterization of the DNA adduct, 2) no …