In Vivo Imaging of Pancreatic Islet Grafts in Diabetes Treatment

DR Arifin, JWM Bulte - Frontiers in Endocrinology, 2021 - frontiersin.org
… (T2D) patients may be achieved by transplantation of pancreatic islets without the need for
exogeneous insulin administration (1–3). Engrafted islets have been shown to stabilize blood …

Multimodal imaging probe development for pancreatic β cells: from fluorescence to PET

NY Kang, JY Lee, SH Lee, IH Song… - Journal of the …, 2020 - ACS Publications
… On the basis of these criteria, we herein report a novel β-cell probe, PiF (pancreatic islet
fluorinated probe), with a dual-modality application both for optical and PET imaging of the β-cell

Tools for bioimaging pancreatic β cells in diabetes

NY Kang, AAP Soetedjo, NS Amirruddin… - Trends in Molecular …, 2019 - cell.com
… In this review we discuss the molecular imaging techniques that are currently available for
… The unique cytoarchitecture of human pancreatic islets has implications for islet cell function…

Unravelling innervation of pancreatic islets

RF Hampton, M Jimenez-Gonzalez, SA Stanley - Diabetologia, 2022 - Springer
… Now, state-of-the art techniques such as 3D imaging of pancreatic innervation and targeted
in vivo neuromodulation provide further insights into the anatomy and physiological roles of …

Heterogeneity of the human pancreatic islet

MP Dybala, M Hara - Diabetes, 2019 - Am Diabetes Assoc
… We hypothesized that depending on how a given islet was cut and imaged in 2D, some
regions would show such structures. Therefore, we tried to reproduce similar 2D views by …

A Trimodal Imaging Platform for Tracking Viable Transplanted Pancreatic Islets In Vivo: F-19 MR, Fluorescence, and Bioluminescence Imaging

A Gálisová, V Herynek, E Swider, E Sticová… - Molecular Imaging and …, 2019 - Springer
… magnetic resonance imaging (MRI) with sensitive and convenient optical imaging provides
… and viability of transplanted pancreatic islet grafts. In this study, pancreatic islets (PIs) were …

[HTML][HTML] Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

M Wu, MYY Lee, V Bahl, D Traum, J Schug… - Cell reports, 2021 - cell.com
… by different cell types within the islet environment. Here, in order to obtain such a
multiplexed view of all critical cell types and states in the T2D pancreas, we used imaging mass …

Structural basis for delta cell paracrine regulation in pancreatic islets

R Arrojo e Drigo, S Jacob, CF García-Prieto… - Nature …, 2019 - nature.com
… Using in vivo optogenetics and high-speed Ca 2+ imaging, we show that these … cell to reach
a large number of beta cells within the islet. This provides for efficient regulation of beta cell

[HTML][HTML] Observing islet function and islet-immune cell interactions in live pancreatic tissue slices

MK Huber, DM Drotar, H Hiller… - Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
image of a live human pancreatic tissue slice with islets indicated by red arrows. (B)
Reflected light image of a live human pancreatic tissue slice with islets … light image of an islet (…

Deciphering the complex communication networks that orchestrate pancreatic islet function

J Weitz, D Menegaz, A Caicedo - Diabetes, 2021 - Am Diabetes Assoc
… synthetic strategies to decode complex cell-cell interactions in the pancreatic islet. Left: In
analytical approaches the islet is broken down, either literally or using imaging tools, to dissect …