… immunotherapy is based upon the principle that adaptations in immune surveillance and
the tumor … mutated DNA of altered proteins which are antigenic, and which serve as tumoral …

… alterations in the epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase
(ALK) genes were randomized to receive either pembrolizumab … are not optimal candidates for …

… immunotherapy has the potential to enhance clinical outcomes by increasing anti-tumor
immune responses in the presence of abundant tumor-… of histologic changes is understood. …

… toward stimulating immunity in cancer. This article reviews the immunotherapies currently in
… enhance response rates and integrate immunotherapy into the definitive-treatment setting. …

… to the seven steps of Cancer-Immunity Cycle as proposed by … such as HPV, genetic alterations,
neoantigens and smoking … and neck tumours making the former better candidates for IO. …

… This review aims to explore immunotherapy (immune checkpoint inhibitors (ICI), therapeutic
… and the host immune system, where modifications in immunological surveillance and the …

… Currently, the majority of head and neck cancers present with … perceived by host immune
system as the “altered self” and … , HNSCCs represent good candidates for immunotherapy, …

… The intricate mechanism involved in the immunity of head and neck cancers has … The
study reports differences in immunological potency attributable to alteration of polymer and the …

… our readers a broader picture of the immunotherapy comparing classical HNSCCs to NPC.
… and proliferation, changes in metabolite- and cytokine-rich tumor microenvironments, and …

… of cancer cells by the host immune system: the immune system … TME stromal cells are
genetically altered and differ from … with immunotherapy, potentially leading to missed opportunities …