Matrix metalloproteinases: Expression, regulation and role in the immunopathology of tuberculosis

N Sabir, T Hussain, MH Mangi, D Zhao… - Cell …, 2019 - Wiley Online Library
TBTB immunopathology that directly involves inhibition of matrix metalloproteinase (MMP)
activity to hinder matrix destruction and reduce the morbidity and mortality associated with TB.…

Immunopathogenesis in HIV-associated pediatric tuberculosis

H Xu, RV Blair, RS Veazey, X Wang - Pediatric research, 2022 - nature.com
… pediatric TB. Understanding the mechanisms behind the susceptibility of infants with HIV
to TB and immunopathogenesis is critical for preventing and treating HIV/Mtb coinfection. …

Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System–Tuberculosis

XY Poh, FK Loh, JS Friedland, CWM Ong - Frontiers in Immunology, 2022 - frontiersin.org
… The presence of neutrophils in human CNS tuberculomas … -α (TNF-α) result in
immunopathology in CNS-TB (10–13). Neutrophils … in driving CNS-TB immunopathology, …

Pathogenesis of tuberculosis

DB Reddy, JJ Ellner - Clinical tuberculosis, 2020 - taylorfrancis.com
… in protection and immunopathology will be considered. Immune responses in human TB will
be … Finally, the impact of HIV-1 on the development of TB and the effect of TB on HIV disease …

Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infection

D Sheerin, N Peton, W Vo, CC Allison, X Wang… - Iscience, 2022 - cell.com
tuberculosis (TB) increase the risk of COVID-19 mortality and severe disease. To identify
mechanisms of immunopathogenic interaction between COVID-19 and TB, we … of TB infection. …

The immunopathology of tuberculosis, the mode of action of the Bacillus Calmette-Guérin, of the tuberculin and of the immunotherapy

R Maes - Biomedical and Biotechnology Research Journal …, 2019 - journals.lww.com
… [ 4 ] This review addresses the immunopathology of Mycobacterium tuberculosis, the
action of the vaccine, the meaning of a positive tuberculin, and the advantages of an …

[HTML][HTML] The immunopathogenesis of tuberculous pericarditis

P Howlett, E Du Bruyn, H Morrison, IC Godsent… - Microbes and …, 2020 - Elsevier
… Despite being a severe form of tuberculosis, we have a limited understanding of the
immunopathology of TB pericarditis. The four-stage model of pathogenesis, while developed …

Human pulmonary tuberculosis: understanding the immune response in the bronchoalveolar system

MT Herrera, S Guzmán-Beltrán, K Bobadilla… - Biomolecules, 2022 - mdpi.com
… to elucidate the role of AECs in active or latent TB. The difficulty in assessing the response
of AECs in the human lung during active TB limits our understanding of their role in disease …

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx

TG Kang, KW Kwon, K Kim, I Lee, MJ Kim, SJ Ha… - Nature …, 2022 - nature.com
… I IFN signature and TB immunopathology in TB-susceptible mouse … by LCMV Arm on TB
immunopathology. Therefore, we … determinant of TB immunopathology upon viral coinfection. …

Nos2−/− mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis

XY Poh, JM Hong, C Bai, QH Miow, PM Thong… - Journal of …, 2022 - Springer
TB model that demonstrates neurobehavioral changes with similar immunopathology with
human CNS-TB… CNS-TB model that resembled human CNS-TB immunopathology, exhibiting …