Neurosteroids and seizure activity

B Miziak, M Chrościńska-Krawczyk… - Frontiers in …, 2020 - frontiersin.org
… can suppress epileptic seizures, yet they do not affect in any way … the onset of the first
spontaneous seizure. During this time, … (99) examined the impact of ALLO on epileptiform activity

Metyrapone abolishes spike–wave discharge seizures in genetic absence epilepsy rats from Strasbourg by reducing stress hormones

G Dezsi, E Ozturk, G Harris, C Paul, TJ O'Brien… - …, 2023 - Wiley Online Library
… , the effects of metyrapone in patients with epilepsy has not … exposures influence spontaneous
seizure activity. As such, … that elevated corticosterone is related to seizure expression; …

Transcranial direct current stimulation reduces anxiety, depression and plasmatic corticosterone in a rat model of atypical generalized epilepsy

FV Gouveia, J Germann, CC Oliveira, MC Castro… - Neuroscience, 2022 - Elsevier
epilepsy showing spontaneous spike-wave discharges … a main effect of treatment and a
significant treatment by … to investigate the effect of tDCS on seizure frequency. Other studies …

Dealing with the storm: An overview of seizure precipitants and spontaneous seizure worsening in drug-resistant epilepsy

E Bartolini, JW Sander - Epilepsy & Behavior, 2019 - Elsevier
seizure frequency to avoid medication side effects related to … correlation between cortisol
levels and interictal discharges [… epileptic encephalopathies and, more rarely, in temporal lobe …

[HTML][HTML] Dexamethasone attenuates low-frequency brainwave disturbances following acute seizures induced by pentylenetetrazol in Wistar rats

RM Ribeiro, EP da Silveira, VC Santos… - Experimental and …, 2024 - Elsevier
… for the reduction of acute epileptiform activity in the brain, while … study assesses the effects
of short-term treatment with DEX … that cortisol levels increase during seizures to neutralize the …

Hypothalamic-pituitary-adrenal axis targets for the treatment of epilepsy

T Basu, J Maguire, JA Salpekar - Neuroscience letters, 2021 - Elsevier
… between seizure frequency and cortisol levels, where patients with … epileptiform activity and
longer duration seizures [49]. These effects persist up to 2 weeks after the final corticosterone

Allopregnanolone and pregnanolone are reduced in the hippocampus of epileptic rats, but only allopregnanolone correlates with seizure frequency

C Lucchi, AM Costa, C Rustichelli, G Biagini - Neuroendocrinology, 2021 - karger.com
… mechanism to control the epileptic activity in TLE. However, no … -steroids and spontaneous
seizure frequency by simple linear … affect the efficiency of GABA A -mediated inhibition in the …

Efficacy and safety of corticosteroids and ACTH in epileptic syndromes beyond Infantile Epileptic Spasms Syndrome (IESS): A systematic review and meta‐analysis

R Korinthenberg, T Bast, E Haberlandt, U Stephani… - …, 2024 - Wiley Online Library
… ) and corticosteroid treatment in children with epilepsy other … Others collected spontaneous
reports on AEs from parents/… positive effects of ESES/LKS in comparison to other epilepsy

Effect of prednisolone in a kindling model of epileptic seizures in rats on cytokine and intestinal microbiota diversity

AMDL de Lima, G de Lima Rosa, EFM Guzzo… - Epilepsy & Behavior, 2024 - Elsevier
spontaneous and recurring epileptic seizures resulting from hyper-synchronized electrical
discharges … as prednisolone (a corticosteroid recognized for its anti-inflammatory effects and …

Does stress trigger seizures? Evidence from experimental models

DS Reddy, W Thompson, G Calderara - … behavioral aspects of epilepsy …, 2021 - Springer
… , cortisol also has detrimental effects on neuronal activity, … spontaneous or induced genetic
modifications that lead to … , neuronal inhibition, and effects on epileptic activity during both the …