The molecular mechanisms supporting the homeostasis and activation of dendritic epidermal T cell and its role in promoting wound healing

C Chen, Z Meng, H Ren, N Zhao, R Shang… - Burns & …, 2021 - academic.oup.com
… in the process of wound healing leads to impairment of TCR signaling and DETC activation,
… STAT signalling pathways are involved in the processes of skin injury and wound repair via …

Skin barrier immunity and ageing

ES Chambers, M Vukmanovic‐Stejic - Immunology, 2020 - Wiley Online Library
… up for the slow repopulation from mature LCs.24 Langerhans … contribute to wound healing,
and heal nerves upon tissue injury.… of skin-derived CD4 + T cells was not impaired with age in …

Skin resident γδ T cell function and regulation in wound repair

LD Munoz, MJ Sweeney, JM Jameson - International Journal of …, 2020 - mdpi.com
… the role of T cells in wound repair and tissue maintenance with a … wound healing and
impaired clonal expansion within the wound, thus TCR signaling via LAT is required for epidermal

Regulatory T cells in skin regeneration and wound healing

S Knoedler, L Knoedler, M Kauke-Navarro… - Military Medical …, 2023 - Springer
… The release of chemical signaling reagents triggers the activation and polymerization of
fibrin … Characterized by impaired and/or delayed wound repair, such wounds do not properly …

Skin γδ T cells and their function in wound healing

W Hu, R Shang, J Yang, C Chen, Z Liu… - Frontiers in …, 2022 - frontiersin.org
Impaired epidermal to DETCs signaling slows wound repair (173), and it has been found that
the insufficient activation of DETCs upon injury leads to abnormal wound healing … in elderly

Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication

R Vu, S Jin, P Sun, D Haensel, QH Nguyen, M Dragan… - Cell reports, 2022 - cell.com
… Delayed and often impaired wound healing in the elderly presents major medical and … ,
and signaling mediators of putative cell-cell communications in young and aged skin wounds. …

Get in touch with dendritic epithelial T cells!

F Thelen, DA Witherden - Frontiers in immunology, 2020 - frontiersin.org
… and signaling in the context of epidermal γδT cell development and … Similarly, DETC
surrounding a skin graft show slow … responses and favors rapid wound healing both in humans …

Aging and homeostasis of the hypodermis in the age-related deterioration of skin function

M Liu, F Lu, J Feng - Cell Death & Disease, 2024 - nature.com
… , delayed wound healing, and loss of cell-cell communication… with age can subsequently
impair homeostasis in skin tissues… surface of T cells and subsequently suppress T cell activation…

Tideglusib promotes wound healing in aged skin by activating PI3K/Akt pathway

J Sun, H Zhao, C Shen, S Li, W Zhang, J Ma… - Stem Cell Research & …, 2022 - Springer
… epithelium and impaired wound healing. As a major type of … on signaling pathways of
EpiSCs and wound healing of aged … In addition to slower wound healing rates, aged rats also …

[HTML][HTML] The pathobiology of skin aging: new insights into an old dilemma

E Russell-Goldman, GF Murphy - The American journal of pathology, 2020 - Elsevier
… deficiencies of aging skin, including deficient wound healing (a … skin of elderly individuals,
whereas the number of T cells in … lost or impaired in terms of T-cell receptor diversity with age. …