Hypertension-induced cognitive impairment: from pathophysiology to public health

Z Ungvari, P Toth, S Tarantini, CI Prodan… - Nature Reviews …, 2021 - nature.com
high blood pressure include an enhanced pressure-induced myogenic constriction response
of segmentally connected cerebral arteries … of cerebral arteries to hypertension is impaired

[PDF][PDF] Impaired endothelium-dependent and endothelium-independent systemic vasodilatory reserve in pulmonary hypertension regardless the clinical group: A …

M Demirel, Ş Külahçıoğlu, HC Tokgöz… - Anatolian Journal of …, 2021 - jag.journalagent.com
… decreased NO production by cerebral endothelial cells, impairment in perception of dyspnea
response) assesses the hyperemia occurring in medium muscular arteries as a response to …

Endothelial dysfunction as a factor leading to arterial hypertension

D Drożdż, M Drożdż, M Wójcik - Pediatric Nephrology, 2023 - Springer
… with the impairment of endothelium-dependent vasodilation and … ability of the cerebral
arterioles. Cognitive deficits in … ability to enhance cerebral blood flow in response to increased …

Mechanisms and clinical implications of endothelial dysfunction in arterial hypertension

P Ambrosino, T Bachetti, SE D'Anna… - Journal of …, 2022 - mdpi.com
… since they are able to respond to humoral and hemodynamic … , which results in impaired
endothelium-dependent vascular … conduit arteries [66]. Conversely, the fact that microvascular …

Plasticity of cerebral microvascular structure and mechanics during hypertension and following recovery of arterial pressure

R Sabharwal, MW Chapleau… - American Journal …, 2022 - journals.physiology.org
… We examined changes in cerebral arterioles at the onset of hypertension and the … ANG
II for 14 days impaired neurovascular coupling and endothelium-dependent vasodilation (54). …

High systolic blood pressure induces cerebral microvascular endothelial dysfunction, neurovascular unit damage, and cognitive decline in mice

O de Montgolfier, A Pinçon, P Pouliot, MA Gillis… - …, 2019 - Am Heart Assoc
… mice, the endothelium-dependent dilatory responses were strongly reduced in cerebral
arteries … , demonstrating endothelial damage and dysfunction after an abnormally high PP and …

Increased vascular contractility in hypertension results from impaired endothelial calcium signaling

C Wilson, X Zhang, C Buckley, HR Heathcote… - …, 2019 - Am Heart Assoc
… Neither are endothelium-dependent contractions to acetylcholine. In the present study,
although contractile responses of mesenteric arteries were augmented, vasodilation was …

[HTML][HTML] Impact of impaired cerebral blood flow autoregulation on cognitive impairment

S Wang, C Tang, Y Liu, JJ Border, RJ Roman… - Frontiers in …, 2022 - frontiersin.org
… lab demonstrated that middle cerebral arteries (MCAs) isolated … (B) Cerebral pial arteries
and arterioles constrict in response … of cognitive impairment after the induction of hypertension, …

Systolic hypertension-induced neurovascular unit disruption magnifies vascular cognitive impairment in middle-age atherosclerotic LDLr−/−:hApoB+/+ mice

O de Montgolfier, P Pouliot, MA Gillis, G Ferland… - Geroscience, 2019 - Springer
… TAC impaired endothelium-dependent dilation in WT mice … a Endothelium-dependent dilatory
responses (%) to acetylcholine (ACh) were measured in ipsilateral middle cerebral arteries

Activation of the central renin-angiotensin system causes local cerebrovascular dysfunction

TM De Silva, ML Modrick, JL Grobe, FM Faraci - Stroke, 2021 - Am Heart Assoc
… study, vertebral arteries from hypertensive humans (the sex … was impaired in cerebral arteries
and parenchymal arterioles… -309) produce endothelium-dependent vasodilation. Inhibition …