Dual catalytic DNA circuit-induced gold nanoparticle aggregation: An enzyme-free and colorimetric strategy for amplified detection of nucleic acids

H Ravan, M Amandadi, M Hassanshahian… - International Journal of …, 2020 - Elsevier
… engineered a FRET-based two-layer DNA circuit for real-time … by combining a feed-forward
catalytic DNA circuit with … is triggered by executing the catalytic DNA circuit and forming the …

Developing a colorimetric nucleic acid-responsive DNA hydrogel using DNA proximity circuit and catalytic hairpin assembly

S Khajouei, H Ravan, A Ebrahimi - Analytica Chimica Acta, 2020 - Elsevier
… In this approach, we demonstrate the feasibility of monitoring a nucleic acid target through
an enzyme-free, sensitive, and simple method. The detecting system underwent three steps, …

Customizable aptamer transducer network designed for feed-forward coupling

T Hachigian, D Lysne, E Graugnard, J Lee - ACS omega, 2021 - ACS Publications
… into DNA strand displacement networks for feed-forward … as feed-forward inputs to two
previously studied catalytic reaction … be implemented in two-layer feed-forward reaction networks. …

Colorimetric detection of miRNA-21 by DNAzyme-coupled branched DNA constructs

E Hosseinzadeh, H Ravan, A Mohammadi… - Talanta, 2020 - Elsevier
… Non-enzymatic catalytic devices based on strand displacement are … in a 2% agarose gel
using cold Tris-acetate-EDTA buffer at a … Essentially, the enzyme-free approaches take place …

Multiplex monitoring of Alzheimer associated miRNAs based on the modular logic circuit operation and doping of catalytic hairpin assembly

A Ebrahimi, H Ravan, M Mehrabani - Biosensors and Bioelectronics, 2020 - Elsevier
… of a set of hairpins catalyzed cascaded DNA self-assembly reactions … enzyme-free nature
of the CHA reaction remarkably enhanced the number of signal products. In this pursuit, using

Principles and applications of nucleic acid strand displacement reactions

FC Simmel, B Yurke, HR Singh - Chemical reviews, 2019 - ACS Publications
… produced enzyme-free catalytic systems, all DNA chemical … Figure 1 is a schematic of a DNA
hybridization reaction. The … two DNA circles rolling against each other, using the same fuel/…

Borderline Boolean states improve the biosensing applications of DNA circuits

S Mirzayi, H Ravan, S Soltanian - International Journal of Biological …, 2022 - Elsevier
… designed a colorimetric multilevel DNA circuit to determine … can be evaluated using a simple
colorimetric device. Today, … In the presence of I1 according to the catalytic harpin assembly (…

Colorimetric nanoplatform for visual determination of cancer cells via target-catalyzed hairpin assembly actuated aggregation of gold nanoparticles

H Ravan, A Norouzi, N Sanadgol, E Hosseinzadeh - Microchimica Acta, 2020 - Springer
… In conclusion, by using a DNA circuit, we have successfully engineered a novel colorimetric
enzyme-free signal amplification strategy for efficient detection of cancer cells. The principle …

Enzyme-free fluorometric assay for chloramphenicol based on double stirring bar-assisted dual signal amplification

F Hong, X Lin, Y Wu, Y Dong, Y Cao, F Hu, N Gan - Microchimica Acta, 2019 - Springer
Schematic representation of a new method for the detection of chloramphenicol by using two
… The siDNA can trigger catalytic hairpin assembly (CHA) to form many double DNA strands …

A DNA Aptamer Transducer Designed Toward Rapid Biosensor Development: A Novel Approach to Modular Biosensing Platforms

TZ Hachigian - 2023 - search.proquest.com
… are typically fluorometric or colorimetric sensors that rely on … can be chained to a catalytic
network for signal amplification. … be implemented in two-layer feed-forward reaction networks. …