Beyond growth factors: macrophage-centric strategies for angiogenesis

AL Nolfi, MN Behun, CC Yates, BN Brown… - Current Pathobiology …, 2020 - Springer
… Though delivery of a single pro-angiogenic molecule from a scaffold may not produce the …
of these mechanisms and enhance to the angiogenic response of these biomaterials. Another …

Harnessing macrophages for vascularization in tissue engineering

EM Moore, JL West - Annals of biomedical engineering, 2019 - Springer
increased neovascularization in the cornea. This study suggests that the activation of
macrophages can influence angiogenesis. … The localized recruitment of AMs correlated with …

Macrophages of diverse phenotypes drive vascularization of engineered tissues

PL Graney, S Ben-Shaul, S Landau, A Bajpai… - Science …, 2020 - science.org
angiogenesis was also highly enriched in response to M1 … during angiogenesis to facilitate
vessel sprouting. In contrast, … day) of M1 macrophages enhanced angiogenesis, but long-term …

Tissue-resident and recruited macrophages in primary tumor and metastatic microenvironments: potential targets in cancer therapy

T Cotechini, A Atallah, A Grossman - Cells, 2021 - mdpi.com
… liposomes enhance the anti-tumor and anti-angiogenic effects … small molecule inhibitors to
improve anti-cancer responses [203]. … but tumor-localized therapy response? With advancing …

Current strategies to target tumor-associated-macrophages to improve anti-tumor immune responses

C Anfray, A Ummarino, F Torres Andon, P Allavena - Cells, 2019 - mdpi.com
… the other hand, macrophages localized in areas of normoxia, … anti-angiogenic therapy was
significantly improved with the co… small molecule inhibitors also showed increased infiltration …

Local targeting of lung-tumor-associated macrophages with pulmonary delivery of a CSF-1R inhibitor for the treatment of breast cancer lung metastases

SS Alhudaithi, RM Almuqbil, H Zhang… - Molecular …, 2020 - ACS Publications
… , play a central role in angiogenesis and metastasis, and are … recruitment of macrophages
that localize around neoplastic cells, … to an improvement in the adaptive antitumor response, as …

[HTML][HTML] Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

J Zheng, J Jiang, Y Pu, T Xu, J Sun… - Frontiers in …, 2023 - ncbi.nlm.nih.gov
… drug delivery platforms is also highlighted, offering improved … TAMs have been identified
as a key inducer of angiogenesis, … research of targeted delivery of small molecule inhibitors of …

Macrophage-mediated cancer drug delivery

HF Wang, Y Liu, G Yang, CX Zhao - Materials Today Sustainability, 2021 - Elsevier
angiogenesis, and drug resistance [19,20]. Accumulating evidence suggests that an increased
… monocyte recruitment by inhibiting key macrophage-recruiting chemokines such as CCL2 …

Drug delivery to macrophages: A review of nano-therapeutics targeted approach for inflammatory disorders and cancer

M Mukhtar, H Ali, N Ahmed, R Munir… - … on Drug Delivery, 2020 - Taylor & Francis
… Therefore, selective localization of drug or peptide remains to be … Moreover, validation of
molecular and cellular targets is … IL-4 improved angiogenesis in the presence of macrophages. …

Engineering biomaterials to tailor the microenvironment for macrophage–endothelium interactions

Y Guan, L Racioppi, S Gerecht - Nature Reviews Materials, 2023 - nature.com
angiogenic behaviours of ECs. For example, it was discovered that pro-regenerative murine
BMDMs increased … membrane molecules can recognize the surface adhesion molecules on …