Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms

J Zheng, J Jiang, Y Pu, T Xu, J Sun, Q Zhang… - … in Bioengineering and …, 2023 - frontiersin.org
… drug delivery platforms is also highlighted, offering improved … TAMs have been identified
as a key inducer of angiogenesis, … research of targeted delivery of small molecule inhibitors of …

Macrophages as promising carriers for nanoparticle delivery in anticancer therapy

A Wróblewska, A Szczygieł… - International Journal …, 2023 - Taylor & Francis
… depleted TAMs, reduced angiogenesis, and prevented the … for the delivery of anticancer
drugs due to their better … receptors and adhesion molecules using genetic engineering, as well …

CD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1

S Durlanik, K Fundel-Clemens, C Viollet, HJ Huber… - Scientific Reports, 2021 - nature.com
… Based on quantification analysis done by flow cytometry, we detected increasedangiogenesis,
tumor cell invasion and motility, TAM can suppress the anti-tumor T cell responses 45 . In …

[图书][B] Magnetically Actuated Alginate Scaffolds: Effects on Macrophage Function and Regenerative Outcomes

L Steele - 2020 - search.proquest.com
angiogenesis requires sustained, localized delivery of … , it significantly increased the expression
of several angiogenic factors … By day 10 pi, the macrophage-recruiting hydrogels display …

[HTML][HTML] HIF1α epigenetically repressed macrophages via CRISPR/Cas9-EZH2 system for enhanced cancer immunotherapy

Y Dong, S Zhang, X Gao, D Yin, T Wang, Z Li, Z Wan… - Bioactive Materials, 2021 - Elsevier
angiogenesis. Together, our study has not only identified a promising cellular and molecular
… macrophages would hijack existent macrophage recruiting signals and activate immune …

Angiogenesis in lymph nodes is a critical regulator of immune response and lymphoma growth

L Menzel, UE Höpken, A Rehm - Frontiers in immunology, 2020 - frontiersin.org
… that supports angiogenesis and increased LN vascularization (1… RA is presumably provided
by neurons localized adjacent to … molecules and is not a reliable indicator of angiogenesis in …

Macrophage polarization states in the tumor microenvironment

AJ Boutilier, SF Elsawa - International journal of molecular sciences, 2021 - mdpi.com
increased in inflammatory and angiogenic settings. Ang2 expression in cultured endothelial
cells is increased … therapy response in murine models of several different tumor types [139]. …

Targeting macrophages: friends or foes in disease?

JA Ardura, G Rackov, E Izquierdo, V Alonso… - Frontiers in …, 2019 - frontiersin.org
responses, causing tissue damage or helping in tissue repair. Knowledge in macrophage
polarization has significantly increased in the … Therefore, dissection of the molecular basis of …

Tumor-associated macrophages in cancer: recent advancements in cancer nanoimmunotherapies

N Kumari, SH Choi - Journal of Experimental & Clinical Cancer Research, 2022 - Springer
… and angiogenesis while suppressing the immune response and … local delivery of
nanotherapeutics to nearby tumor cells and … MMPs, all of which increase angiogenesis through …

Macrophages as a potential immunotherapeutic target in solid cancers

AK Mishra, S Banday, R Bharadwaj, A Ali, R Rashid… - Vaccines, 2022 - mdpi.com
… Nevertheless, several small molecule and antibody-based … -1 resulted in an enhanced
tumor response compared to anti-… delivery of IFNγ inhibited tumor growth and angiogenesis by …